Lot-Documented
HPLC-Verified
US Pharmacist
Same Reorder Price
GLPs · TRIPLE GLP-1/GIP/GLUCAGON AGONIST
Retatrutide
30 mg · Lyophilized vial · 39 AA
Retatrutide — pharmacy-verified, lot-tested, and shipped from our 503B facility in Dallas. Released only after a US-licensed pharmacist signs off on the batch.
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Single- Purity Guarantee. If a lot fails our ≥99% HPLC standard, full refund + replacement.
- Lot-specific COA on demand — anytime, free
- Same reorder price — forever, no upcharge
$135.00
Single
— About this compound
Retatrutide.
Class · Triple agonist at GIP, GLP-1, and glucagon receptors (synthetic peptide)
Origin. Developed by Eli Lilly. First publicly characterized by Coskun et al. in 2022 as the next-generation evolution of the dual-incretin concept embodied in tirzepatide.
Retatrutide (research code LY3437943) is a single-molecule triple agonist that activates the GIP receptor, the GLP-1 receptor, and the glucagon receptor. The triple-incretin pharmacology represents an attempt to combine the insulin-sensitizing and appetite-modulating effects of GLP-1/GIP agonism with the energy-expenditure effects of glucagon receptor activation.
The compound is currently in late-stage clinical investigation for obesity and type 2 diabetes. Public literature is concentrated in Phase 1–2 trial reports and preclinical pharmacology.
— Common research applications
- Triple-incretin pharmacology
- Energy expenditure research
- Comparative incretin-agonist studies
- Metabolic flux models
— Mechanism
How it's been studied.
Picomolar-affinity agonist at GIP, GLP-1, and glucagon receptors. The balanced triple-agonist profile is hypothesized to combine glycemic control (GLP-1/GIP) with increased energy expenditure (glucagon) in metabolic research models.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
2381089-83-2
Molecular weight
5419 Da
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
30 mg
Purity (HPLC)
≥99%
Amino acids
39
Half-life
~6 days (early clinical pharmacokinetic reports).
Solubility
Reconstitutes in bacteriostatic water.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Retatrutide.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit lot follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled at a 503B facility.
Lyophilized in a cleanroom at our 503B outsourcing facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- 503B outsourcing facility, FDA-registered
- ISO-certified manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every lot before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-lot
- ≥99% purity floor — every batch
- Chromatogram archived for every lot
- 04
Sign-off
A US-licensed pharmacist releases the lot.
No batch ships without a pharmacist reviewing the chromatogram, identity report, and lot documentation. The pharmacist holds the release authority.
- US-licensed pharmacist on every lot
- Pharmacist holds release authority
- No batch ships unsigned — ever
- 05
Dispatch
Ships from Dallas in 48 hours.
Vials labeled with lot ID, tested date, and CAS. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from Dallas, TX
- Lot ID printed on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific lot by emailing rx@meritsciences.com with the lot number from your vial label.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept
Coskun T, Urva S, Roell WC, et al. · Cell Metabolism · 2022
- 02
Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Jastreboff AM, Kaplan LM, Frías JP, et al. · New England Journal of Medicine · 2023
- 03
Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial
Rosenstock J, Frias J, Jastreboff AM, et al. · The Lancet · 2023
Inclusion of a reference does not constitute a clinical claim or recommendation.
— The Pharmacist's Seal
Triple-agonist — newer than Tirzepatide. Limited literature but increasing research interest.
Merit Sciences Pharmacy Team
US-licensed pharmacist · 503B outsourcing facility · Dallas, TX
— Common Questions
Got questions.
Why does Merit ship lyophilized?+
Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.
How do I verify my lot's COA?+
Your vial label carries the lot number. Use that number to pull the COA on our site at any time — the COA for your specific batch lives at /coa/[lot-id] and stays accessible for the life of the product.
What does "pharmacy-verified" actually mean?+
A US-licensed pharmacist on our team reviews every batch before release. They sign off on the lot's purity, identity, and release. No batch ships without that sign-off — and that's what separates Merit from a reseller catalog.
Will my bank flag this purchase?+
Statements show as Merit Sciences LLC. Standard merchant descriptor — does not trigger category-code flags. All major cards via Stripe; PayPal accepted at checkout.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From Dallas, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
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Our team answers compound questions, lot questions, and protocol questions — same business day. No bots, no tickets.
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