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Peptides · 28-AMINO-ACID PEPTIDE
Thymosin Alpha-1 10 mg
Lyophilized vial · 28 AA
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$131.99
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Thymosin Alpha-1 in brief
Thymosin Alpha-1 is a 28-amino-acid thymic peptide studied for immune modulation, with a clinical trial record from outside the United States. Thymosin alpha-1 (thymalfasin) is approved as a prescription drug in some countries outside the United States but has never been approved by the FDA. Supplied for research use only.
— About this compound
Thymosin Alpha-1.
Class · 28-amino-acid N-acetylated peptide (acetyl-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn)
Origin. Isolated from bovine thymus extract (Thymosin Fraction 5) by Allan Goldstein at the Albert Einstein College of Medicine in the early 1970s; sequence first published in 1977. Approved for clinical use as Zadaxin in over 35 countries for chronic hepatitis B and as a vaccine adjuvant.
Thymosin Alpha-1 (Tα1) is a 28-amino-acid N-acetylated peptide derived from prothymosin alpha (ProTα). Among the family of thymic peptides, Tα1 is the most extensively characterized in the published immunology and infectious-disease research literature.
The peptide is identical in sequence across mammalian species, suggesting strong evolutionary conservation. In approved clinical use abroad it is administered subcutaneously; in research contexts it is most commonly investigated for effects on T-cell maturation, dendritic-cell function, and innate-immune signaling.
— Common research applications
- Immunomodulation research
- Antiviral pathway investigation
- T-cell maturation studies
- Vaccine adjuvant research
- TLR9 signaling pharmacology
— Mechanism
How it's been studied.
Toll-like receptor 9 (TLR9) and MyD88-dependent signaling pathway activation has been reported as the dominant proximal mechanism. Downstream effects include dendritic-cell maturation, enhanced Th1 cytokine production, and modulation of regulatory T-cell populations in preclinical models.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
62304-98-7
Molecular weight
3108.3 Da
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
10 mg
Purity (HPLC)
≥99%
Amino acids
28
Half-life
~2 hr (subcutaneous administration, preclinical models).
Solubility
Highly water-soluble. Physicochemical context only. Merit Sciences publishes no reconstitution or preparation procedures.
View the March 2026 batch certificate for Thymosin Alpha-1 10 mg → or browse every certificate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Thymosin Alpha-1.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
From lab to bedside: emerging clinical applications of thymosin α1
Goldstein AL, Goldstein AL · Expert Opinion on Biological Therapy · 2009
- 02
Thymosin alpha 1: from bench to bedside
Garaci E, Pica F, Serafino A, et al. · Annals of the New York Academy of Sciences · 2007
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Go deeper
Mechanism, published research and peer-reviewed references for Thymosin Alpha-1, with no product attached.
Research review on The Assay, Merit’s editorial publication: Thymosin Alpha-1: Approved Abroad, Unapproved in the US
— Common Questions
Got questions.
Is Thymosin Alpha-1 FDA-approved?+
Thymosin alpha-1 (thymalfasin) is approved as a prescription drug in some countries outside the United States but has never been approved by the FDA. Supplied for research use only.
How is each batch of Thymosin Alpha-1 tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed. Merit identifies batches by date: the current certificate for Thymosin Alpha-1 10 mg is the March 2026 batch, 99.618% purity by HPLC, published at meritsciences.com/coa/MRT-2603-02. The QR code on each vial opens the same page. Open the March 2026 batch certificate →
What does the published research on Thymosin Alpha-1 show?+
Reviews by Goldstein (Expert Opinion on Biological Therapy 2009) and Garaci (Annals of the New York Academy of Sciences 2007) summarize clinical studies of thymalfasin, mainly in chronic viral hepatitis and as an immune adjuvant. Most of that clinical record comes from trials run outside the United States. The Thymosin Alpha-1 monograph at meritsciences.com/library/thymosin-alpha-1 lists the references, and The Assay, Merit's editorial publication, reviews the evidence at theassay.co/articles/thymosin-alpha-1-research-review. Read the Thymosin Alpha-1 monograph →
What is Thymosin Alpha-1?+
Thymosin Alpha-1 (Tα1) is a 28-amino-acid N-acetylated peptide derived from prothymosin alpha (ProTα). Among the family of thymic peptides, Tα1 is the most extensively characterized in the published immunology and infectious-disease research literature.
How does Thymosin Alpha-1 work?+
Toll-like receptor 9 (TLR9) and MyD88-dependent signaling pathway activation has been reported as the dominant proximal mechanism. Downstream effects include dendritic-cell maturation, enhanced Th1 cytokine production, and modulation of regulatory T-cell populations in preclinical models.
What class of compound is Thymosin Alpha-1?+
Thymosin Alpha-1 is classified as 28-amino-acid N-acetylated peptide (acetyl-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn).
What is the reported half-life of Thymosin Alpha-1?+
~2 hr (subcutaneous administration, preclinical models).
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
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