Batch-Documented
HPLC-Verified
Independent Assay
Same Reorder Price
Peptides · 28-AMINO-ACID PEPTIDE
Thymosin Alpha-1 10 mg
Lyophilized vial · 28 AA
Thymosin Alpha-1 — independently assayed, batch-tested, and shipped from our fulfillment facility in San Antonio. Released only after an independent laboratory returns its results for the batch.
Per vial
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SingleShips within 48 hours from San Antonio
UPS Ground · tracked + insured · released after independent lab testing
- Purity Guarantee. If a batch fails our ≥99% HPLC standard, full refund + replacement.
- Batch certificate in the COA library, anytime, free
- Same reorder price — forever, no upcharge
$131.99
Single
— About this compound
Thymosin Alpha-1.
Class · 28-amino-acid N-acetylated peptide (acetyl-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn)
Origin. Isolated from bovine thymus extract (Thymosin Fraction 5) by Allan Goldstein at the Albert Einstein College of Medicine in the early 1970s; sequence first published in 1977. Approved for clinical use as Zadaxin in over 35 countries for chronic hepatitis B and as a vaccine adjuvant.
Thymosin Alpha-1 (Tα1) is a 28-amino-acid N-acetylated peptide derived from prothymosin alpha (ProTα). Among the family of thymic peptides, Tα1 is the most extensively characterized in the published immunology and infectious-disease research literature.
The peptide is identical in sequence across mammalian species, suggesting strong evolutionary conservation. In approved clinical use abroad it is administered subcutaneously; in research contexts it is most commonly investigated for effects on T-cell maturation, dendritic-cell function, and innate-immune signaling.
— Common research applications
- Immunomodulation research
- Antiviral pathway investigation
- T-cell maturation studies
- Vaccine adjuvant research
- TLR9 signaling pharmacology
— Mechanism
How it's been studied.
Toll-like receptor 9 (TLR9) and MyD88-dependent signaling pathway activation has been reported as the dominant proximal mechanism. Downstream effects include dendritic-cell maturation, enhanced Th1 cytokine production, and modulation of regulatory T-cell populations in preclinical models.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
62304-98-7
Molecular weight
3108.3 Da
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
10 mg
Purity (HPLC)
≥99%
Amino acids
28
Half-life
~2 hr (subcutaneous administration, preclinical models).
Solubility
Highly water-soluble; stable in bacteriostatic water.
View lab results for Thymosin Alpha-1 → or search by compound.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Thymosin Alpha-1.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- ISO-certified US facility
- ISO-certified manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing rx@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
From lab to bedside: emerging clinical applications of thymosin α1
Goldstein AL, Goldstein AL · Expert Opinion on Biological Therapy · 2009
- 02
Thymosin alpha 1: from bench to bedside
Garaci E, Pica F, Serafino A, et al. · Annals of the New York Academy of Sciences · 2007
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Common Questions
Got questions.
What is Thymosin Alpha-1?+
Thymosin Alpha-1 (Tα1) is a 28-amino-acid N-acetylated peptide derived from prothymosin alpha (ProTα). Among the family of thymic peptides, Tα1 is the most extensively characterized in the published immunology and infectious-disease research literature.
How does Thymosin Alpha-1 work?+
Toll-like receptor 9 (TLR9) and MyD88-dependent signaling pathway activation has been reported as the dominant proximal mechanism. Downstream effects include dendritic-cell maturation, enhanced Th1 cytokine production, and modulation of regulatory T-cell populations in preclinical models.
What class of compound is Thymosin Alpha-1?+
Thymosin Alpha-1 is classified as 28-amino-acid N-acetylated peptide (acetyl-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn).
What is the reported half-life of Thymosin Alpha-1?+
~2 hr (subcutaneous administration, preclinical models).
Why does Merit ship lyophilized?+
Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.
How do I check the certificate for my batch?+
The QR code on every vial opens our COA library. Search by compound to find the certificate for the batch currently shipping. No account and no request form, and the library keeps every certificate we have released.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do — that's what separates Merit from a reseller catalog.
Will my bank flag this purchase?+
Statements show as Merit Sciences LLC. Standard merchant descriptor — does not trigger category-code flags. All major cards and PayPal accepted at checkout.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
Question we didn't answer?
Our team answers compound questions, batch questions, and protocol questions — same business day. No bots, no tickets.
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