— Research monograph
NAD+
The central redox coenzyme studied across cellular-energy and aging models.
- Class
- Pyridine nucleotide coenzyme — NOT a peptide
- Half-life (research)
- Variable by route; intracellular NAD+ pools are continuously cycled.
- Origin
- NAD was discovered by Arthur Harden and William John Young in 1906 during fermentation research. Sirtuin biology — a major focus of contemporary NAD+ research — emerged through the work of Leonard Guarente, David Sinclair, and others in the late 1990s and 2000s.
- Solubility
- Highly water-soluble. Reconstitute in bacteriostatic water.
What is NAD+?
Nicotinamide Adenine Dinucleotide (NAD+) is a pyridine nucleotide coenzyme present in every living cell. It is not a peptide and does not fit the strict "research peptide" category — it is stocked because the cellular-pathway literature on NAD+ is deep, the reorder pattern is consistent, and many of the researchers buying Merit peptides also work with NAD+.
NAD+ functions both as a redox cofactor and as a substrate for an expanding family of NAD-consuming enzymes including the sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38.
How does NAD+ work?
Redox cofactor in catabolic and biosynthetic pathways (NAD+/NADH cycling). Substrate for sirtuin deacetylase activity. Substrate for PARP-mediated DNA damage signaling. Central to mitochondrial electron-transport-chain function.
Research applications
- Sirtuin biology research
- Mitochondrial bioenergetics
- PARP / DNA-damage-response signaling
- Cellular aging models
- Metabolic flux studies
Handling & reconstitution
NAD+ ships as a sealed, lyophilized (freeze-dried) powder and is reconstituted with bacteriostatic water for laboratory handling. Highly water-soluble. Reconstitute in bacteriostatic water. Concentration equals vial mass divided by diluent volume.
See the NAD+ reconstitution protocol for a step-by-step guide and an interactive research calculator (vial size → diluent → draw volume).
Frequently asked questions
What is NAD+?
Nicotinamide Adenine Dinucleotide (NAD+) is a pyridine nucleotide coenzyme present in every living cell. It is not a peptide and does not fit the strict "research peptide" category — it is stocked because the cellular-pathway literature on NAD+ is deep, the reorder pattern is consistent, and many of the researchers buying Merit peptides also work with NAD+. Merit supplies it as a lyophilized research compound for research use only — not for human or veterinary use.
How does NAD+ work?
Redox cofactor in catabolic and biosynthetic pathways (NAD+/NADH cycling). Substrate for sirtuin deacetylase activity. Substrate for PARP-mediated DNA damage signaling. Central to mitochondrial electron-transport-chain function. Mechanistic descriptions summarize published preclinical findings and are not clinical claims.
What is the half-life of NAD+?
Variable by route; intracellular NAD+ pools are continuously cycled. Values reflect preclinical or research-context reports, not clinical pharmacokinetics.
How is NAD+ reconstituted for research?
A lyophilized vial is reconstituted with bacteriostatic water; concentration equals vial mass divided by diluent volume. See the NAD+ reconstitution protocol for a step-by-step guide and a research calculator.
Is Merit NAD+ for human use?
No. It is sold strictly for research use only — not for human or veterinary use, and not for diagnostic or therapeutic use. Every lot ships with a certificate of analysis documenting ≥99% HPLC purity.
References
- NAD+ and sirtuins in aging and disease. Imai S, Guarente L. Trends in Cell Biology, 2014 · PMID 24786309
- NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Yoshino J, Baur JA, Imai S. Cell Metabolism, 2018 · PMID 29249689
- NAD+ in aging, metabolism, and neurodegeneration. Verdin E. Science, 2015 · PMID 26785480
- Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Rajman L, Chwalek K, Sinclair DA. Cell Metabolism, 2018 · PMID 29514064
For research use only. Not for human or veterinary use. Not FDA-approved. Reference information summarized from published literature — not medical or dosing advice.