Lot-Documented
HPLC-Verified
US Pharmacist
Same Reorder Price
Cofactors · COENZYME
NAD+ 500 mg
Lyophilized vial
NAD+ — pharmacy-verified, lot-tested, and shipped from our facility in Dallas. Released only after a US-licensed pharmacist signs off on the batch.
Per vial
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Single- Purity Guarantee. If a lot fails our ≥99% HPLC standard, full refund + replacement.
- Lot-specific COA on demand — anytime, free
- Same reorder price — forever, no upcharge
$84.99
Single
— About this compound
NAD+.
Class · Pyridine nucleotide coenzyme — NOT a peptide
Origin. NAD was discovered by Arthur Harden and William John Young in 1906 during fermentation research. Sirtuin biology — a major focus of contemporary NAD+ research — emerged through the work of Leonard Guarente, David Sinclair, and others in the late 1990s and 2000s.
Nicotinamide Adenine Dinucleotide (NAD+) is a pyridine nucleotide coenzyme present in every living cell. It is not a peptide and does not fit the strict "research peptide" category — it is stocked because the cellular-pathway literature on NAD+ is deep, the reorder pattern is consistent, and many of the researchers buying Merit peptides also work with NAD+.
NAD+ functions both as a redox cofactor and as a substrate for an expanding family of NAD-consuming enzymes including the sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38.
— Common research applications
- Sirtuin biology research
- Mitochondrial bioenergetics
- PARP / DNA-damage-response signaling
- Cellular aging models
- Metabolic flux studies
— Mechanism
How it's been studied.
Redox cofactor in catabolic and biosynthetic pathways (NAD+/NADH cycling). Substrate for sirtuin deacetylase activity. Substrate for PARP-mediated DNA damage signaling. Central to mitochondrial electron-transport-chain function.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
53-84-9
Molecular weight
663.4 Da
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
500 mg
Purity (HPLC)
≥99%
Amino acids
—
Half-life
Variable by route; intracellular NAD+ pools are continuously cycled.
Solubility
Highly water-soluble. Reconstitute in bacteriostatic water.
— Lab analysis
Proof of identity.
Independent HPLC-UV/MS verification on every batch. The chromatogram shown is the actual analysis for the lot currently shipping — ≥99%, released after US-pharmacist sign-off.
Need the COA for a specific lot? Email rx@meritsciences.com with the lot number from your vial label.
HPLC chromatogram · lot TBD · ≥99%
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for NAD+.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit lot follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- ISO-certified US facility
- ISO-certified manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every lot before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-lot
- ≥99% purity floor — every batch
- Chromatogram archived for every lot
- 04
Sign-off
A US-licensed pharmacist releases the lot.
No batch ships without a pharmacist reviewing the chromatogram, identity report, and lot documentation. The pharmacist holds the release authority.
- US-licensed pharmacist on every lot
- Pharmacist holds release authority
- No batch ships unsigned — ever
- 05
Dispatch
Ships from Dallas in 48 hours.
Vials labeled with lot ID, tested date, and CAS. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from Dallas, TX
- Lot ID printed on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific lot by emailing rx@meritsciences.com with the lot number from your vial label.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
NAD+ and sirtuins in aging and disease
Imai S, Guarente L · Trends in Cell Biology · 2014
- 02
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino J, Baur JA, Imai S · Cell Metabolism · 2018
- 03
- 04
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Rajman L, Chwalek K, Sinclair DA · Cell Metabolism · 2018
Inclusion of a reference does not constitute a clinical claim or recommendation.
— The Pharmacist's Seal
A coenzyme, not a peptide. Stocked because the cellular-pathway literature is deep and reorders are consistent.
Merit Sciences Pharmacy Team
US-licensed pharmacist · ISO-certified facility · Dallas, TX
— Pairs Well With
Researchers stack this with.
The Cellular Stack
Mitochondrial · coenzyme · signaling
NAD+, MOTS-c, and GHK-Cu — three molecules in the cellular-pathway literature, in one shipment.
$308.97 · save 12%
— Common Questions
Got questions.
What is NAD+?+
Nicotinamide Adenine Dinucleotide (NAD+) is a pyridine nucleotide coenzyme present in every living cell. It is not a peptide and does not fit the strict "research peptide" category — it is stocked because the cellular-pathway literature on NAD+ is deep, the reorder pattern is consistent, and many of the researchers buying Merit peptides also work with NAD+.
How does NAD+ work?+
Redox cofactor in catabolic and biosynthetic pathways (NAD+/NADH cycling). Substrate for sirtuin deacetylase activity. Substrate for PARP-mediated DNA damage signaling. Central to mitochondrial electron-transport-chain function.
What class of compound is NAD+?+
NAD+ is classified as pyridine nucleotide coenzyme — NOT a peptide.
What is the reported half-life of NAD+?+
Variable by route; intracellular NAD+ pools are continuously cycled.
Why does Merit ship lyophilized?+
Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.
How do I verify my lot's COA?+
Your vial label carries the lot number. Use that number to pull the COA on our site at any time — the COA for your specific batch lives at /coa/[lot-id] and stays accessible for the life of the product.
What does "pharmacy-verified" actually mean?+
A US-licensed pharmacist on our team reviews every batch before release. They sign off on the lot's purity, identity, and release. No batch ships without that sign-off — and that's what separates Merit from a reseller catalog.
Will my bank flag this purchase?+
Statements show as Merit Sciences LLC. Standard merchant descriptor — does not trigger category-code flags. All major cards and PayPal accepted at checkout.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From Dallas, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
Question we didn't answer?
Our team answers compound questions, lot questions, and protocol questions — same business day. No bots, no tickets.
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