Lot-Documented
HPLC-Verified
Independent Assay
Same Reorder Price
Cofactors · COENZYME
NAD+ 500 mg
Lyophilized vial
NAD+ — independently assayed, lot-tested, and shipped from our fulfillment facility in San Antonio. Released only after an independent laboratory returns its results for the lot.
Per vial
Select your pack size
Single- Purity Guarantee. If a lot fails our ≥99% HPLC standard, full refund + replacement.
- Lot-specific COA on demand — anytime, free
- Same reorder price — forever, no upcharge
$84.99
Single
— About this compound
NAD+.
Class · Pyridine nucleotide coenzyme — NOT a peptide
Origin. NAD was discovered by Arthur Harden and William John Young in 1906 during fermentation research. Sirtuin biology — a major focus of contemporary NAD+ research — emerged through the work of Leonard Guarente, David Sinclair, and others in the late 1990s and 2000s.
Nicotinamide Adenine Dinucleotide (NAD+) is a pyridine nucleotide coenzyme present in every living cell. It is not a peptide and does not fit the strict "research peptide" category — it is stocked because the cellular-pathway literature on NAD+ is deep, the reorder pattern is consistent, and many of the researchers buying Merit peptides also work with NAD+.
NAD+ functions both as a redox cofactor and as a substrate for an expanding family of NAD-consuming enzymes including the sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38.
— Common research applications
- Sirtuin biology research
- Mitochondrial bioenergetics
- PARP / DNA-damage-response signaling
- Cellular aging models
- Metabolic flux studies
— Mechanism
How it's been studied.
Redox cofactor in catabolic and biosynthetic pathways (NAD+/NADH cycling). Substrate for sirtuin deacetylase activity. Substrate for PARP-mediated DNA damage signaling. Central to mitochondrial electron-transport-chain function.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
53-84-9
Molecular weight
663.4 Da
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
500 mg
Purity (HPLC)
≥99%
Amino acids
—
Half-life
Variable by route; intracellular NAD+ pools are continuously cycled.
Solubility
Highly water-soluble. Reconstitute in bacteriostatic water.
View lab results for NAD+ → — or search any lot number from your label.
— Lab analysis
Proof of identity.
Independent HPLC-UV/MS verification on every batch. The chromatogram shown is the actual analysis for the lot currently shipping — ≥99%, released after an independent assay.
Need the COA for a specific lot? Email rx@meritsciences.com with the lot number from your vial label.
HPLC chromatogram · lot TBD · ≥99%
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for NAD+.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit lot follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- ISO-certified US facility
- ISO-certified manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every lot before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-lot
- ≥99% purity floor — every batch
- Chromatogram archived for every lot
- 04
Release
The lot is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published against that lot number.
- Independent laboratory on every lot
- Certificate published before sale
- Lot number resolves to its own report
- 05
Dispatch
Ships from San Antonio in 48 hours.
Vials labeled with lot ID, tested date, and CAS. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- Lot ID printed on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific lot by emailing rx@meritsciences.com with the lot number from your vial label.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
NAD+ and sirtuins in aging and disease
Imai S, Guarente L · Trends in Cell Biology · 2014
- 02
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino J, Baur JA, Imai S · Cell Metabolism · 2018
- 03
- 04
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Rajman L, Chwalek K, Sinclair DA · Cell Metabolism · 2018
Inclusion of a reference does not constitute a clinical claim or recommendation.
— The Lot Note
A coenzyme, not a peptide. Stocked because the cellular-pathway literature is deep and reorders are consistent.
Merit Sciences Lab Team
Independently assayed · ISO-certified US facility · Ships from San Antonio, TX
— Pairs Well With
Researchers stack this with.
The Cellular Stack
Mitochondrial · coenzyme · signaling
NAD+, MOTS-c, and GHK-Cu — three molecules in the cellular-pathway literature, in one shipment.
$308.97 · save 12%
— Common Questions
Got questions.
What is NAD+?+
Nicotinamide Adenine Dinucleotide (NAD+) is a pyridine nucleotide coenzyme present in every living cell. It is not a peptide and does not fit the strict "research peptide" category — it is stocked because the cellular-pathway literature on NAD+ is deep, the reorder pattern is consistent, and many of the researchers buying Merit peptides also work with NAD+.
How does NAD+ work?+
Redox cofactor in catabolic and biosynthetic pathways (NAD+/NADH cycling). Substrate for sirtuin deacetylase activity. Substrate for PARP-mediated DNA damage signaling. Central to mitochondrial electron-transport-chain function.
What class of compound is NAD+?+
NAD+ is classified as pyridine nucleotide coenzyme — NOT a peptide.
What is the reported half-life of NAD+?+
Variable by route; intracellular NAD+ pools are continuously cycled.
Why does Merit ship lyophilized?+
Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.
How do I verify my lot's COA?+
Your vial label carries the lot number. Use that number to pull the COA on our site at any time — the COA for your specific batch lives at /coa/[lot-id] and stays accessible for the life of the product.
What does "independently assayed" actually mean?+
Every lot is tested by a laboratory independent of the facility that made it, and the certificate is published before the lot is sold. You read the same identity and purity figures we do — that's what separates Merit from a reseller catalog.
Will my bank flag this purchase?+
Statements show as Merit Sciences LLC. Standard merchant descriptor — does not trigger category-code flags. All major cards and PayPal accepted at checkout.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
Question we didn't answer?
Our team answers compound questions, lot questions, and protocol questions — same business day. No bots, no tickets.
Email the team →— Same Family
