Lot-Documented
HPLC-Verified
US Pharmacist
Same Reorder Price
Cofactors · COPPER TRIPEPTIDE
GHK-Cu 100 mg
Lyophilized vial · 3 AA
GHK-Cu — pharmacy-verified, lot-tested, and shipped from our facility in Dallas. Released only after a US-licensed pharmacist signs off on the batch.
Per vial
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Single- Purity Guarantee. If a lot fails our ≥99% HPLC standard, full refund + replacement.
- Lot-specific COA on demand — anytime, free
- Same reorder price — forever, no upcharge
$85.99
Single
— About this compound
GHK-Cu.
Class · Copper-binding tripeptide (glycyl-L-histidyl-L-lysine + Cu²⁺)
Origin. Isolated from human serum by Loren Pickart in 1973 as a factor that, when added to liver cultures from elderly donors, restored a younger gene-expression profile.
GHK is a naturally occurring tripeptide with the amino-acid sequence glycyl-L-histidyl-L-lysine. When complexed with copper(II), the resulting GHK-Cu chelate forms a planar coordination structure that is the bioactive form referenced in most of the published research literature.
GHK-Cu is one of the most extensively studied copper-binding peptides in cell-biology research. Pickart and colleagues have demonstrated effects on a wide range of gene-expression endpoints in cultured cells, with particular focus on dermal fibroblast and hair follicle research models.
— Common research applications
- Dermal fibroblast research
- Hair follicle biology
- Gene-expression studies
- Wound-healing cell-culture models
- Copper-trafficking pathway investigation
— Mechanism
How it's been studied.
Modulates gene expression in cultured fibroblasts (downregulation of TGF-β and upregulation of decorin reported in dermal research models). Facilitates copper transport across cell membranes. Has been associated with anti-inflammatory cytokine profiles and fibroblast activation in preclinical work.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
49557-75-7
Molecular weight
340.4 Da
Formula
—
Sequence
GHK
Format
Lyophilized powder
Vial dose
100 mg
Purity (HPLC)
≥99%
Amino acids
3
Half-life
Short serum half-life (minutes) reported in preclinical pharmacokinetic studies.
Solubility
Highly soluble in bacteriostatic water; presents a distinctive blue color in solution from the Cu²⁺ chelate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for GHK-Cu.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit lot follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- ISO-certified US facility
- ISO-certified manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every lot before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-lot
- ≥99% purity floor — every batch
- Chromatogram archived for every lot
- 04
Sign-off
A US-licensed pharmacist releases the lot.
No batch ships without a pharmacist reviewing the chromatogram, identity report, and lot documentation. The pharmacist holds the release authority.
- US-licensed pharmacist on every lot
- Pharmacist holds release authority
- No batch ships unsigned — ever
- 05
Dispatch
Ships from Dallas in 48 hours.
Vials labeled with lot ID, tested date, and CAS. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from Dallas, TX
- Lot ID printed on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific lot by emailing rx@meritsciences.com with the lot number from your vial label.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Pickart L, Margolina A · International Journal of Molecular Sciences · 2018
- 02
The human tri-peptide GHK and tissue remodeling
Pickart L · Journal of Biomaterials Science, Polymer Edition · 2008
- 03
GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
Pickart L, Vasquez-Soltero JM, Margolina A · BioMed Research International · 2015
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Pairs Well With
Researchers stack this with.
The Cellular Stack
Mitochondrial · coenzyme · signaling
NAD+, MOTS-c, and GHK-Cu — three molecules in the cellular-pathway literature, in one shipment.
$308.97 · save 12%
— Common Questions
Got questions.
What is GHK-Cu?+
GHK is a naturally occurring tripeptide with the amino-acid sequence glycyl-L-histidyl-L-lysine. When complexed with copper(II), the resulting GHK-Cu chelate forms a planar coordination structure that is the bioactive form referenced in most of the published research literature.
How does GHK-Cu work?+
Modulates gene expression in cultured fibroblasts (downregulation of TGF-β and upregulation of decorin reported in dermal research models). Facilitates copper transport across cell membranes. Has been associated with anti-inflammatory cytokine profiles and fibroblast activation in preclinical work.
What class of compound is GHK-Cu?+
GHK-Cu is classified as copper-binding tripeptide (glycyl-L-histidyl-L-lysine + Cu²⁺).
What is the reported half-life of GHK-Cu?+
Short serum half-life (minutes) reported in preclinical pharmacokinetic studies.
Why does Merit ship lyophilized?+
Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.
How do I verify my lot's COA?+
Your vial label carries the lot number. Use that number to pull the COA on our site at any time — the COA for your specific batch lives at /coa/[lot-id] and stays accessible for the life of the product.
What does "pharmacy-verified" actually mean?+
A US-licensed pharmacist on our team reviews every batch before release. They sign off on the lot's purity, identity, and release. No batch ships without that sign-off — and that's what separates Merit from a reseller catalog.
Will my bank flag this purchase?+
Statements show as Merit Sciences LLC. Standard merchant descriptor — does not trigger category-code flags. All major cards and PayPal accepted at checkout.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From Dallas, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
Question we didn't answer?
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