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Cofactors · TETRAPEPTIDE
Epitalon 50 mg
Lyophilized vial · 4 AA
Per vial
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SingleShips within 48 hours from San Antonio
UPS Ground · tracked + insured · released after independent lab testing
- Purity Guarantee. If a batch fails our ≥99% HPLC standard, full refund + replacement.
- Batch certificate in the COA library, anytime, free
- Same reorder price — forever, no upcharge
$114.99
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Epitalon in brief
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase and circadian signaling, mostly in cell and animal models. Epitalon is not approved by the FDA for any use. An FDA advisory committee recommended it for the 503A compounding list in July 2026, but no FDA rule has followed. Supplied for research use only.
— About this compound
Epitalon.
Class · Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
Origin. Developed at the St. Petersburg Institute of Bioregulation and Gerontology by Vladimir Khavinson and colleagues, modeled on bioactive fractions of bovine pineal extract (epithalamin) characterized in earlier Russian peptide-bioregulation research.
Epitalon is a synthetic tetrapeptide composed of L-alanine, L-glutamic acid, L-aspartic acid, and L-glycine. It is among the most-studied "peptide bioregulators" in the Russian gerontology research literature.
Much of the published literature on Epitalon derives from the Khavinson group and its collaborators. The peptide has been investigated primarily in the context of circadian rhythm regulation, telomerase activity in cultured cells, and rodent lifespan models.
— Common research applications
- Telomerase activity research
- Circadian rhythm investigation
- Pineal axis research
- Cellular aging models
- Peptide bioregulator pharmacology
— Mechanism
How it's been studied.
Reported telomerase induction and telomere elongation in cultured human somatic cells. Modulation of circadian rhythm gene expression and melatonin signaling in preclinical models. Specific receptor or transcription-factor targets remain incompletely characterized in the public literature.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
307297-39-8
Molecular weight
390.4 Da
Formula
—
Sequence
AEDG
Format
Lyophilized powder
Vial dose
50 mg
Purity (HPLC)
≥99%
Amino acids
4
Half-life
Short circulating half-life characteristic of short peptides.
Solubility
Highly water-soluble. Physicochemical context only. Merit Sciences publishes no reconstitution or preparation procedures.
View lab results for Epitalon → or browse every certificate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Epitalon.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Khavinson VK, Bondarev IE, Butyugov AA · Bulletin of Experimental Biology and Medicine · 2003
- 02
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice
Anisimov VN, Khavinson VKh, Provinciali M, et al. · Biogerontology · 2003
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Go deeper
Mechanism, published research and peer-reviewed references for Epitalon, with no product attached.
Research review on The Assay, Merit’s editorial publication: Epitalon: What the Published Research Actually Shows
— Common Questions
Got questions.
Is Epitalon FDA-approved?+
Epitalon is not approved by the FDA for any use. An FDA advisory committee recommended it for the 503A compounding list in July 2026, but no FDA rule has followed. Supplied for research use only.
How is each batch of Epitalon tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed, and Merit identifies batches by date rather than by lot number. Published certificates are in the COA library at meritsciences.com/coa, searchable by compound; the QR code on each vial opens its certificate. Search the COA library →
What does the published research on Epitalon show?+
Khavinson (Bulletin of Experimental Biology and Medicine 2003) reported telomerase induction and telomere elongation in cultured human somatic cells, and Anisimov (Biogerontology 2003) reported effects on lifespan and tumor incidence in female mice. Much of the literature comes from the same St. Petersburg research group. The Epitalon monograph at meritsciences.com/library/epitalon lists the references, and The Assay, Merit's editorial publication, reviews the evidence at theassay.co/articles/epitalon-research-review. Read the Epitalon monograph →
What is Epitalon?+
Epitalon is a synthetic tetrapeptide composed of L-alanine, L-glutamic acid, L-aspartic acid, and L-glycine. It is among the most-studied "peptide bioregulators" in the Russian gerontology research literature.
How does Epitalon work?+
Reported telomerase induction and telomere elongation in cultured human somatic cells. Modulation of circadian rhythm gene expression and melatonin signaling in preclinical models. Specific receptor or transcription-factor targets remain incompletely characterized in the public literature.
What class of compound is Epitalon?+
Epitalon is classified as synthetic tetrapeptide (Ala-Glu-Asp-Gly).
What is the reported half-life of Epitalon?+
Short circulating half-life characteristic of short peptides.
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
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