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Peptides · GHRH ANALOG
Sermorelin Acetate 10 mg
Lyophilized vial · 29 AA
Per vial
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UPS Ground · tracked + insured · released after independent lab testing
- Purity Guarantee. If a batch fails our ≥99% HPLC standard, full refund + replacement.
- Batch certificate in the COA library, anytime, free
- Same reorder price — forever, no upcharge
$69.00
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Sermorelin Acetate in brief
Sermorelin Acetate is the 29-amino-acid active fragment of growth-hormone-releasing hormone, studied in growth hormone axis research. Sermorelin was FDA-approved as Geref, which its sponsor discontinued in 2008; in 2013 FDA determined it was not withdrawn for reasons of safety or effectiveness. Research material sold as sermorelin is not FDA-approved. Supplied for research use only.
— About this compound
Sermorelin Acetate.
Class · GHRH receptor agonist — 29-amino-acid fragment of growth-hormone-releasing hormone
Origin. The shortest N-terminal fragment of GHRH retaining full biological activity at GHRH receptors. Synthesized and characterized following identification of full-length GHRH by Guillemin and colleagues in the early 1980s.
Sermorelin is the synthetic acetate salt of GHRH(1-29), the N-terminal 29 amino acids of human growth-hormone-releasing hormone (somatocrinin). It is the shortest GHRH fragment known to retain full intrinsic activity at the GHRH receptor and is among the most-studied secretagogues in the public research literature.
Unlike growth hormone itself, sermorelin acts upstream by stimulating endogenous pituitary GH release in a physiologic pulsatile pattern, preserving negative-feedback regulation by somatostatin and IGF-1.
— Common research applications
- GH / IGF-1 axis research
- Pituitary somatotroph function
- GHRH receptor pharmacology
- Comparative secretagogue studies
— Mechanism
How it's been studied.
Selective agonist at the GHRH receptor on anterior pituitary somatotrophs. Receptor activation triggers cAMP-mediated calcium influx and stimulates pulsatile growth hormone release from pituitary stores.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
86168-78-7
Molecular weight
3357.9 Da
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
10 mg
Purity (HPLC)
≥99%
Amino acids
29
Half-life
~10–20 min (rapid serum clearance is characteristic of GHRH analogs).
Solubility
Highly water-soluble. Physicochemical context only. Merit Sciences publishes no reconstitution or preparation procedures.
View lab results for Sermorelin Acetate → or browse every certificate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Sermorelin Acetate.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?
Walker RF · Clinical Interventions in Aging · 2006
- 02
Sermorelin: a synthetic growth hormone-releasing hormone analogue. Pharmacology and clinical use
Prakash A, Goa KL · BioDrugs · 1999
- 03
Growth-hormone-releasing hormone (1-29) in adults
Khorram O, Laughlin GA, Yen SS · Journal of Clinical Endocrinology and Metabolism · 1997
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Pairs Well With
Researchers stack this with.
The GH-Axis Stack
Secretagogue + downstream
Sermorelin paired with IGF-1 LR3: secretagogue plus downstream growth factor in the same shipment.
$160.99 · save 10%
— Go deeper
Mechanism, published research and peer-reviewed references for Sermorelin, with no product attached.
Research review on The Assay, Merit’s editorial publication: Tesamorelin vs Sermorelin: One Approved, One Discontinued
Research review on The Assay, Merit’s editorial publication: Ipamorelin vs Sermorelin vs CJC-1295: What the Published Research Compares
— Common Questions
Got questions.
Is Sermorelin Acetate FDA-approved?+
Sermorelin was FDA-approved as Geref, which its sponsor discontinued in 2008; in 2013 FDA determined it was not withdrawn for reasons of safety or effectiveness. Research material sold as sermorelin is not FDA-approved. Supplied for research use only. Sermorelin is named on the WADA 2026 Prohibited List under S2 as a growth hormone releasing hormone analogue and is prohibited at all times.
How is each batch of Sermorelin Acetate tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed, and Merit identifies batches by date rather than by lot number. Published certificates are in the COA library at meritsciences.com/coa, searchable by compound; the QR code on each vial opens its certificate. Search the COA library →
What does the published research on Sermorelin Acetate show?+
Prakash (BioDrugs 1999) and Walker (Clinical Interventions in Aging 2006) review its pharmacology as a GHRH(1-29) analog that stimulates pituitary growth hormone release. Khorram (Journal of Clinical Endocrinology and Metabolism 1997) studied GHRH(1-29) in older adults. The Sermorelin monograph at meritsciences.com/library/sermorelin lists the references, and The Assay, Merit's editorial publication, reviews the evidence at theassay.co/articles/tesamorelin-vs-sermorelin. Read the Sermorelin monograph →
What is Sermorelin Acetate?+
Sermorelin is the synthetic acetate salt of GHRH(1-29), the N-terminal 29 amino acids of human growth-hormone-releasing hormone (somatocrinin). It is the shortest GHRH fragment known to retain full intrinsic activity at the GHRH receptor and is among the most-studied secretagogues in the public research literature.
How does Sermorelin Acetate work?+
Selective agonist at the GHRH receptor on anterior pituitary somatotrophs. Receptor activation triggers cAMP-mediated calcium influx and stimulates pulsatile growth hormone release from pituitary stores.
What class of compound is Sermorelin Acetate?+
Sermorelin Acetate is classified as gHRH receptor agonist — 29-amino-acid fragment of growth-hormone-releasing hormone.
What is the reported half-life of Sermorelin Acetate?+
~10–20 min (rapid serum clearance is characteristic of GHRH analogs).
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
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