— Research monograph
Sermorelin
The 29-amino-acid active fragment of growth-hormone-releasing hormone.
- Class
- GHRH receptor agonist — 29-amino-acid fragment of growth-hormone-releasing hormone
- Half-life (research)
- ~10–20 min (rapid serum clearance is characteristic of GHRH analogs).
- Origin
- The shortest N-terminal fragment of GHRH retaining full biological activity at GHRH receptors. Synthesized and characterized following identification of full-length GHRH by Guillemin and colleagues in the early 1980s.
- Solubility
- Highly soluble in bacteriostatic water; stable for ~30 days refrigerated after reconstitution.
What is Sermorelin?
Sermorelin is the synthetic acetate salt of GHRH(1-29), the N-terminal 29 amino acids of human growth-hormone-releasing hormone (somatocrinin). It is the shortest GHRH fragment known to retain full intrinsic activity at the GHRH receptor and is among the most-studied secretagogues in the public research literature.
Unlike growth hormone itself, sermorelin acts upstream by stimulating endogenous pituitary GH release in a physiologic pulsatile pattern, preserving negative-feedback regulation by somatostatin and IGF-1.
How does Sermorelin work?
Selective agonist at the GHRH receptor on anterior pituitary somatotrophs. Receptor activation triggers cAMP-mediated calcium influx and stimulates pulsatile growth hormone release from pituitary stores.
Research applications
- GH / IGF-1 axis research
- Pituitary somatotroph function
- GHRH receptor pharmacology
- Comparative secretagogue studies
Handling & reconstitution
Sermorelin ships as a sealed, lyophilized (freeze-dried) powder and is reconstituted with bacteriostatic water for laboratory handling. Highly soluble in bacteriostatic water; stable for ~30 days refrigerated after reconstitution. Concentration equals vial mass divided by diluent volume.
Frequently asked questions
What is Sermorelin?
Sermorelin is the synthetic acetate salt of GHRH(1-29), the N-terminal 29 amino acids of human growth-hormone-releasing hormone (somatocrinin). It is the shortest GHRH fragment known to retain full intrinsic activity at the GHRH receptor and is among the most-studied secretagogues in the public research literature. Merit supplies it as a lyophilized research compound for research use only — not for human or veterinary use.
How does Sermorelin work?
Selective agonist at the GHRH receptor on anterior pituitary somatotrophs. Receptor activation triggers cAMP-mediated calcium influx and stimulates pulsatile growth hormone release from pituitary stores. Mechanistic descriptions summarize published preclinical findings and are not clinical claims.
What is the half-life of Sermorelin?
~10–20 min (rapid serum clearance is characteristic of GHRH analogs). Values reflect preclinical or research-context reports, not clinical pharmacokinetics.
Is Merit Sermorelin for human use?
No. It is sold strictly for research use only — not for human or veterinary use, and not for diagnostic or therapeutic use. Every lot ships with a certificate of analysis documenting ≥99% HPLC purity.
References
- Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?. Walker RF. Clinical Interventions in Aging, 2006 · PMID 18046908
- Sermorelin: a synthetic growth hormone-releasing hormone analogue. Pharmacology and clinical use. Prakash A, Goa KL. BioDrugs, 1999 · doi:10.2165/00063030-199912020-00007
- Growth-hormone-releasing hormone (1-29) in adults. Khorram O, Laughlin GA, Yen SS. Journal of Clinical Endocrinology and Metabolism, 1997 · PMID 9360512
For research use only. Not for human or veterinary use. Not FDA-approved. Reference information summarized from published literature — not medical or dosing advice.