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Neuropeptides · MELANOCORTIN AGONIST
PT-141 10 mg
Lyophilized vial · 7 AA
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- Purity Guarantee. If a batch fails our ≥99% HPLC standard, full refund + replacement.
- Batch certificate in the COA library, anytime, free
- Same reorder price — forever, no upcharge
$64.99
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PT-141 in brief
PT-141 is bremelanotide, a cyclic heptapeptide melanocortin receptor agonist studied in melanocortin pathway research. Bremelanotide, the molecule known as PT-141, is FDA-approved only as specific branded prescription drug products; research material sold as PT-141 is not one of those products and is not FDA-approved. Supplied for research use only.
— About this compound
PT-141.
Class · Cyclic heptapeptide melanocortin receptor agonist
Origin. Developed by Palatin Technologies as a synthetic analog of α-melanocyte stimulating hormone (α-MSH). Approved by the FDA in 2019 (brand name Vyleesi) for hypoactive sexual desire disorder in premenopausal women.
PT-141 (bremelanotide) is a cyclic heptapeptide analog of α-MSH that acts as a non-selective agonist at melanocortin receptors with preferential activity at MC3R and MC4R. The cyclic structure confers proteolytic stability relative to linear α-MSH analogs.
In contrast to peripheral PDE5-inhibitor mechanisms used by earlier sexual-medicine compounds, the bremelanotide mechanism is central — acting at hypothalamic melanocortin receptors. The compound has been investigated extensively in both preclinical and Phase 3 human research.
— Common research applications
- Melanocortin receptor pharmacology
- Central neuroendocrine signaling
- MC3R / MC4R selectivity research
- Hypothalamic peptide signaling
— Mechanism
How it's been studied.
Non-selective melanocortin receptor agonist with preferential activity at MC3R and MC4R in hypothalamic neuronal populations. Activation modulates downstream neuroendocrine pathways implicated in sexual response in preclinical models.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
189691-06-3
Molecular weight
1025.2 Da
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
10 mg
Purity (HPLC)
≥99%
Amino acids
7
Half-life
~2.7 hr (clinical pharmacokinetic data).
Solubility
Physicochemical context only. Merit Sciences publishes no reconstitution or preparation procedures.
View the May 2026 batch certificate for PT-141 10 mg → or browse every certificate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for PT-141.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist
Pfaus JG, Shadiack A, Van Soest T, et al. · Proceedings of the National Academy of Sciences USA · 2004
- 02
An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist
Diamond LE, Earle DC, Heiman JR, et al. · Journal of Sexual Medicine · 2006
- 03
Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials
Kingsberg SA, Clayton AH, Portman D, et al. · Obstetrics and Gynecology · 2019
Inclusion of a reference does not constitute a clinical claim or recommendation.
— The Batch Note
Neuroendocrine pathway research, centered on MC3R and MC4R melanocortin receptor pharmacology.
Merit Sciences Lab Team
Independently assayed · Licensed US facility · Ships from San Antonio, TX
— Go deeper
Mechanism, published research and peer-reviewed references for PT-141, with no product attached.
Research review on The Assay, Merit’s editorial publication: PT-141 vs Melanotan II: What the Research Compares
— Common Questions
Got questions.
Is PT-141 FDA-approved?+
Bremelanotide, the molecule known as PT-141, is FDA-approved only as specific branded prescription drug products; research material sold as PT-141 is not one of those products and is not FDA-approved. Supplied for research use only.
How is each batch of PT-141 tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed. Merit identifies batches by date: the current certificate for PT-141 10 mg is the May 2026 batch, 99.741% purity by HPLC, published at meritsciences.com/coa/MRT-2605-08. The QR code on each vial opens the same page. Open the May 2026 batch certificate →
What does the published research on PT-141 show?+
Pfaus (PNAS 2004) reported increased sexual solicitation in female rats given the compound. Two randomized phase 3 trials of bremelanotide in premenopausal women with hypoactive sexual desire disorder were published by Kingsberg (Obstetrics and Gynecology 2019). The PT-141 monograph at meritsciences.com/library/pt-141 lists the references, and The Assay, Merit's editorial publication, reviews the evidence at theassay.co/articles/pt-141-vs-melanotan-ii. Read the PT-141 monograph →
What is PT-141?+
PT-141 (bremelanotide) is a cyclic heptapeptide analog of α-MSH that acts as a non-selective agonist at melanocortin receptors with preferential activity at MC3R and MC4R. The cyclic structure confers proteolytic stability relative to linear α-MSH analogs.
How does PT-141 work?+
Non-selective melanocortin receptor agonist with preferential activity at MC3R and MC4R in hypothalamic neuronal populations. Activation modulates downstream neuroendocrine pathways implicated in sexual response in preclinical models.
What class of compound is PT-141?+
PT-141 is classified as cyclic heptapeptide melanocortin receptor agonist.
What is the reported half-life of PT-141?+
~2.7 hr (clinical pharmacokinetic data).
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
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