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SLU-PP-332 5 mg
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SLU-PP-332 in brief
SLU-PP-332 is a synthetic small-molecule agonist of the estrogen-related receptors, which regulate mitochondrial and oxidative-metabolism genes, studied in mice and cells as a candidate exercise mimetic. No human trial has been published. Not approved by the FDA for any use. Supplied for research use only.
— About this compound
SLU-PP-332.
Class · Synthetic small molecule (not a peptide); pan agonist of the estrogen-related receptors ERRα, ERRβ and ERRγ
Origin. First reported in 2023 by Billon, Burris, Walker and colleagues (Saint Louis University, with Salk Institute collaborators) as a pan-ERR agonist with highest potency at ERRα.
SLU-PP-332 is a synthetic small-molecule agonist of the three estrogen-related receptors (ERRα, ERRβ and ERRγ), orphan nuclear receptors that regulate mitochondrial and oxidative-metabolism genes. Billon and colleagues introduced it in 2023 (ACS Chemical Biology), reporting increased mitochondrial function and respiration in a skeletal muscle cell line and, in mice, more oxidative type IIa muscle fibers and longer treadmill endurance. That result is why it is described as a candidate exercise mimetic.
The follow-up literature is in mice and cells. The same group reported higher energy expenditure and fatty acid oxidation, less fat mass accumulation and improved insulin sensitivity in two obese mouse models (JPET 2024). Xu and colleagues reported improved ejection fraction, less fibrosis and better survival in a mouse pressure-overload heart failure model, mediated mainly by ERRγ (Circulation 2024). Wang and colleagues reported reversal of age-related kidney changes in 21-month-old mice (American Journal of Pathology 2023).
No human trial has been published. The only human-derived work is laboratory work on cells, such as myoblasts cultured from muscle biopsies of inactive women (Frontiers in Physiology 2025, a pilot study). A 2026 paper from the originating group describes a chemically distinct successor compound, SLU-PP-915 (JPET 2026). Merit Sciences supplies SLU-PP-332 strictly for laboratory research use, not for human or veterinary use.
— Common research applications
- Estrogen-related receptor pharmacology
- Skeletal muscle mitochondrial function models
- Exercise-mimetic research in mice
- Cardiac metabolism and heart failure models
- Aging kidney models
— Mechanism
How it's been studied.
SLU-PP-332 is described as activating all three estrogen-related receptors, with highest potency at ERRα, and inducing an ERRα-dependent gene program associated with acute aerobic exercise in mouse muscle (Billon, ACS Chemical Biology 2023). ERRs are orphan nuclear receptors, transcription factors with no established endogenous ligand, that regulate genes for mitochondrial function and fatty acid oxidation. In the mouse heart failure model, genetic experiments identified ERRγ rather than ERRα as the main mediator (Xu, Circulation 2024).
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
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Molecular weight
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Formula
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Sequence
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Format
Lyophilized powder
Vial dose
5 mg
Purity (HPLC)
≥99%
Amino acids
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Half-life
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Solubility
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View lab results for SLU-PP-332 → or browse every certificate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for SLU-PP-332.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity
Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, et al. · ACS Chemical Biology · 2023
- 02
A Synthetic ERR Agonist Alleviates Metabolic Syndrome
Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP · The Journal of Pharmacology and Experimental Therapeutics · 2024
- 03
Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function
Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, et al. · Circulation · 2024
- 04
Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney
Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, et al. · The American Journal of Pathology · 2023
- 05
Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study
Bonanni R, Falvino A, Matticari A, Rinaldi AM, D'Arcangelo G, Cifelli P, et al. · Frontiers in Physiology · 2025
- 06
An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity
Billon C, Appourchaux K, Cote I, Burris TP · The Journal of Pharmacology and Experimental Therapeutics · 2026
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Go deeper
Mechanism, published research and peer-reviewed references for SLU-PP-332, with no product attached.
— Common Questions
Got questions.
Is SLU-PP-332 FDA-approved?+
Not approved by the FDA for any use. Supplied for research use only.
How is each batch of SLU-PP-332 tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed, and Merit identifies batches by date rather than by lot number. Published certificates are in the COA library at meritsciences.com/coa, searchable by compound; the QR code on each vial opens its certificate. Search the COA library →
What does the published research on SLU-PP-332 show?+
Billon and colleagues (ACS Chemical Biology 2023) reported more oxidative muscle fibers and longer treadmill endurance in mice given SLU-PP-332, and follow-up mouse studies reported metabolic and cardiac effects (JPET 2024; Circulation 2024). No human trial has been published. The SLU-PP-332 monograph at meritsciences.com/library/slu-pp-332 lists the references. Read the SLU-PP-332 monograph →
What is SLU-PP-332?+
SLU-PP-332 is a synthetic small-molecule agonist of the three estrogen-related receptors (ERRα, ERRβ and ERRγ), orphan nuclear receptors that regulate mitochondrial and oxidative-metabolism genes. Billon and colleagues introduced it in 2023 (ACS Chemical Biology), reporting increased mitochondrial function and respiration in a skeletal muscle cell line and, in mice, more oxidative type IIa muscle fibers and longer treadmill endurance. That result is why it is described as a candidate exercise mimetic.
How does SLU-PP-332 work?+
SLU-PP-332 is described as activating all three estrogen-related receptors, with highest potency at ERRα, and inducing an ERRα-dependent gene program associated with acute aerobic exercise in mouse muscle (Billon, ACS Chemical Biology 2023). ERRs are orphan nuclear receptors, transcription factors with no established endogenous ligand, that regulate genes for mitochondrial function and fatty acid oxidation. In the mouse heart failure model, genetic experiments identified ERRγ rather than ERRα as the main mediator (Xu, Circulation 2024).
What class of compound is SLU-PP-332?+
SLU-PP-332 is classified as synthetic small molecule (not a peptide); pan agonist of the estrogen-related receptors ERRα, ERRβ and ERRγ.
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
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