BPC-157 10 mg

BPC-157 is a synthetic pentadecapeptide corresponding to a partial sequence of a protein identified in human gastric juice. Unlike most peptides used in laboratory work it carries no disulfide bridge, no terminal amidation and no unnatural residues, and it is repeatedly reported as stable in aqueous solution and in gastric juice, which is unusual for a peptide of this length and is one reason it appears so often in oral-administration animal work. The sequence is frequently written with the research code PL 14736 in the earlier literature.

The mechanism most consistently proposed in the literature is angiomodulatory rather than directly mitogenic. Work from the Sikiric group reports upregulation of vascular endothelial growth factor receptor 2 with downstream activation of the Akt and endothelial nitric oxide synthase pathway, and a body of related work situates the peptide as an interacting partner of the nitric oxide system, reported as counteracting both excessive and deficient NO signalling in different injury models rather than acting in a single direction. Separate in vitro work by Chang and colleagues reported increased outgrowth from tendon explants, improved fibroblast survival under hydrogen peroxide stress and dose-dependent fibroblast migration, with FAK-paxillin signalling implicated, and a subsequent paper from the same group reported growth hormone receptor as among the most abundantly upregulated transcripts in treated tendon fibroblasts. These are proposed mechanisms drawn from animal and cell-culture models, reported here as literature and not as established pharmacology in any species.

BPC-157 is classified as synthetic pentadecapeptide, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val — a partial sequence of the human gastric juice protein designated Body Protection Compound.

No reliable human pharmacokinetic figure exists in the peer-reviewed record, and none is asserted here. Circulating half-life values quoted widely in non-academic sources could not be traced to a primary study during preparation of this entry. What the literature does report is unusual stability in aqueous solution and resistance to degradation in human gastric juice, which is the property most frequently cited to explain the peptide appearing in oral-administration rodent protocols. Stated for interpretation of the research literature only.

Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.

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