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Wolverine (BPC-157 + TB-500) 20 mg
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Wolverine (BPC-157 + TB-500) in brief
Wolverine (BPC-157 + TB-500) is a co-formulation of BPC-157, a gastric pentadecapeptide, and TB-500, a thymosin beta-4 fragment, studied mainly in rodent tissue-repair models. Neither BPC-157 nor TB-500 is approved by the FDA for any use, and no FDA-approved product combines them. Supplied for research use only.
— About this compound
Wolverine (BPC-157 + TB-500).
Class · Pentadecapeptide (BPC-157) + Thymosin Beta-4 fragment (TB-500) co-formulation
Origin. BPC-157 was first characterized at the University of Zagreb by the Sikiric laboratory in the early 1990s as a stable fragment of body protection compound, a polypeptide identified in gastric juice. Thymosin Beta-4 (the parent peptide of TB-500) was originally isolated from bovine thymus by Allan Goldstein in 1981.
BPC-157 is a synthetic pentadecapeptide consisting of fifteen amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a fragment of body protection compound, a polypeptide originally identified in human gastric juice. It is notable in the peptide literature for unusually high stability in acidic environments — a property that has made it a frequent subject of preclinical investigation.
TB-500 is a synthetic acetylated 17-amino-acid fragment of Thymosin Beta-4 (Tβ4), a 43-amino-acid peptide naturally expressed in most mammalian tissues. The fragment corresponds to the active actin-binding region of the parent peptide.
The Wolverine co-formulation places both peptides in a single lyophilized vial at 10 mg each. Researchers requesting this blend most commonly cite combined-pathway repair studies as their rationale for the pairing.
— Common research applications
- Tissue-repair pathway investigation
- Tendon and ligament healing models
- Vascular angiogenesis research
- GI mucosal integrity studies
- Actin cytoskeleton dynamics
— Mechanism
How it's been studied.
BPC-157 has been investigated in preclinical models for effects on angiogenesis (VEGF/VEGFR2 axis modulation), nitric oxide system regulation, growth hormone receptor expression, and dopaminergic / serotonergic system interactions. TB-500 functions primarily as an actin-sequestering protein involved in cell motility, organogenesis, and the regulation of actin polymerization in research models. Both peptides remain under active investigation; mechanisms described above reflect preclinical findings, not clinical conclusions.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
—
Molecular weight
—
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
20 mg
Purity (HPLC)
≥99%
Amino acids
—
Half-life
BPC-157: ~4 hr (preclinical, rat). TB-500: not well-characterized in the public literature.
Solubility
Physicochemical context only. Merit Sciences publishes no reconstitution or preparation procedures.
View the July 2026 batch certificate for Wolverine (BPC-157 + TB-500) 20 mg → or browse every certificate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Wolverine (BPC-157 + TB-500).
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Stable Gastric Pentadecapeptide BPC 157-NO-system Relation
Sikiric P, Seiwerth S, Rucman R, et al. · Current Pharmaceutical Design · 2014
- 02
Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications
Sikiric P, Rucman R, Turkovic B, et al. · Current Neuropharmacology · 2016
- 03
Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
Goldstein AL, Hannappel E, Sosne G, Kleinman HK · Expert Opinion on Biological Therapy · 2012
Inclusion of a reference does not constitute a clinical claim or recommendation.
— The Batch Note
The most-studied pentadecapeptide combination in the catalog. Wolverine ships with both BPC-157 and TB-500 co-formulated in one vial.
Merit Sciences Lab Team
Independently assayed · Licensed US facility · Ships from San Antonio, TX
— Pairs Well With
Researchers stack this with.
The Recovery Stack
Tissue + copper-peptide signaling
Wolverine paired with GHK-Cu: the most-stacked pair in our catalog for repair-pathway research.
$185.98 · save 10%
— Go deeper
Mechanism, published research and peer-reviewed references for BPC-157 + TB-500 (Wolverine), with no product attached.
Research review on The Assay, Merit’s editorial publication: BPC-157 vs TB-500: What the Published Research Actually Compares
Research review on The Assay, Merit’s editorial publication: TB-500 vs Thymosin Beta-4: What the Research Covers
— Common Questions
Got questions.
Is Wolverine (BPC-157 + TB-500) FDA-approved?+
Neither BPC-157 nor TB-500 is approved by the FDA for any use, and no FDA-approved product combines them. Supplied for research use only. Both components are named on the WADA 2026 Prohibited List: BPC-157 under S0 and TB-500 under S2.
How is each batch of Wolverine (BPC-157 + TB-500) tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed. Merit identifies batches by date: the current certificate for Wolverine (BPC-157 + TB-500) 20 mg is the July 2026 batch, 99.51% purity by HPLC, published at meritsciences.com/coa/COA-2026-Z6RSEN. The QR code on each vial opens the same page. Open the July 2026 batch certificate →
What does the published research on Wolverine (BPC-157 + TB-500) show?+
No study of the combination has been published; the literature belongs to each component. BPC-157's record is mostly rat repair studies from the Sikiric group (Current Pharmaceutical Design 2014), and thymosin beta-4's repair biology is reviewed by Goldstein (Expert Opinion on Biological Therapy 2012). The BPC-157 + TB-500 (Wolverine) monograph at meritsciences.com/library/bpc-157-tb-500 lists the references, and The Assay, Merit's editorial publication, reviews the evidence at theassay.co/articles/bpc-157-vs-tb-500. Read the BPC-157 + TB-500 (Wolverine) monograph →
What is Wolverine (BPC-157 + TB-500)?+
BPC-157 is a synthetic pentadecapeptide consisting of fifteen amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a fragment of body protection compound, a polypeptide originally identified in human gastric juice. It is notable in the peptide literature for unusually high stability in acidic environments — a property that has made it a frequent subject of preclinical investigation.
How does Wolverine (BPC-157 + TB-500) work?+
BPC-157 has been investigated in preclinical models for effects on angiogenesis (VEGF/VEGFR2 axis modulation), nitric oxide system regulation, growth hormone receptor expression, and dopaminergic / serotonergic system interactions. TB-500 functions primarily as an actin-sequestering protein involved in cell motility, organogenesis, and the regulation of actin polymerization in research models. Both peptides remain under active investigation; mechanisms described above reflect preclinical findings, not clinical conclusions.
What class of compound is Wolverine (BPC-157 + TB-500)?+
Wolverine (BPC-157 + TB-500) is classified as pentadecapeptide (BPC-157) + Thymosin Beta-4 fragment (TB-500) co-formulation.
What is the reported half-life of Wolverine (BPC-157 + TB-500)?+
BPC-157: ~4 hr (preclinical, rat). TB-500: not well-characterized in the public literature.
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
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