Lot-Documented
HPLC-Verified
US Pharmacist
Same Reorder Price
Semaglutide 10 mg
Lyophilized vial
— Vial size
Semaglutide — pharmacy-verified, lot-tested, and shipped from our facility in Dallas. Released only after a US-licensed pharmacist signs off on the batch.
Per vial
Select your pack size
Single- Purity Guarantee. If a lot fails our ≥99% HPLC standard, full refund + replacement.
- Lot-specific COA on demand — anytime, free
- Same reorder price — forever, no upcharge
$64.99
Single
— About this compound
Semaglutide.
Class · Long-acting glucagon-like peptide-1 (GLP-1) receptor agonist (acylated GLP-1 analog)
Origin. Developed by Novo Nordisk as a structurally engineered, albumin-binding analog of native GLP-1 designed for an extended half-life. The broader GLP-1 analog field grew out of incretin physiology characterized from the 1980s onward.
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1), a 31-amino-acid incretin hormone. Engineering modifications — a C18 fatty-diacid side chain that promotes reversible binding to serum albumin, plus substitutions that resist DPP-4 degradation — give it a markedly longer circulating half-life than native GLP-1, a central focus of the analog literature.
In research, semaglutide is used as a reference GLP-1 receptor agonist for studying incretin signaling, pancreatic islet biology, and energy-metabolism models. It is a regulated therapeutic in approved human channels; the Merit Sciences offering is supplied strictly for research use and not for human or veterinary administration.
— Common research applications
- GLP-1 receptor signaling research
- Incretin and islet-biology models
- Energy-metabolism and appetite-pathway studies
- Comparative GLP-1 analog pharmacology
— Mechanism
How it's been studied.
Selective agonism at the GLP-1 receptor, a class B G-protein-coupled receptor. Receptor engagement modulates glucose-dependent insulin secretion, glucagon release, and central pathways implicated in satiety in preclinical models.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
—
Molecular weight
—
Formula
—
Sequence
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Format
Lyophilized powder
Vial dose
10 mg
Purity (HPLC)
≥99%
Amino acids
—
Half-life
~7 days (engineered albumin binding; pharmacokinetic literature).
Solubility
Water-soluble; reconstitutes in bacteriostatic water.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Semaglutide.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit lot follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- ISO-certified US facility
- ISO-certified manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every lot before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-lot
- ≥99% purity floor — every batch
- Chromatogram archived for every lot
- 04
Sign-off
A US-licensed pharmacist releases the lot.
No batch ships without a pharmacist reviewing the chromatogram, identity report, and lot documentation. The pharmacist holds the release authority.
- US-licensed pharmacist on every lot
- Pharmacist holds release authority
- No batch ships unsigned — ever
- 05
Dispatch
Ships from Dallas in 48 hours.
Vials labeled with lot ID, tested date, and CAS. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from Dallas, TX
- Lot ID printed on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific lot by emailing rx@meritsciences.com with the lot number from your vial label.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
The Discovery and Development of Liraglutide and Semaglutide
Knudsen LB, Lau J · Frontiers in Endocrinology · 2019
- 02
GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art
Nauck MA, Quast DR, Wefers J, et al. · Molecular Metabolism · 2021
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Common Questions
Got questions.
What is Semaglutide?+
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1), a 31-amino-acid incretin hormone. Engineering modifications — a C18 fatty-diacid side chain that promotes reversible binding to serum albumin, plus substitutions that resist DPP-4 degradation — give it a markedly longer circulating half-life than native GLP-1, a central focus of the analog literature.
How does Semaglutide work?+
Selective agonism at the GLP-1 receptor, a class B G-protein-coupled receptor. Receptor engagement modulates glucose-dependent insulin secretion, glucagon release, and central pathways implicated in satiety in preclinical models.
What class of compound is Semaglutide?+
Semaglutide is classified as long-acting glucagon-like peptide-1 (GLP-1) receptor agonist (acylated GLP-1 analog).
What is the reported half-life of Semaglutide?+
~7 days (engineered albumin binding; pharmacokinetic literature).
Why does Merit ship lyophilized?+
Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.
How do I verify my lot's COA?+
Your vial label carries the lot number. Use that number to pull the COA on our site at any time — the COA for your specific batch lives at /coa/[lot-id] and stays accessible for the life of the product.
What does "pharmacy-verified" actually mean?+
A US-licensed pharmacist on our team reviews every batch before release. They sign off on the lot's purity, identity, and release. No batch ships without that sign-off — and that's what separates Merit from a reseller catalog.
Will my bank flag this purchase?+
Statements show as Merit Sciences LLC. Standard merchant descriptor — does not trigger category-code flags. All major cards and PayPal accepted at checkout.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From Dallas, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
Question we didn't answer?
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