Batch-Documented
HPLC-Verified
Independent Assay
Same Reorder Price
Semaglutide 10 mg
Lyophilized vial
— Vial size
Per vial
Select your pack size
SingleShips within 48 hours from San Antonio
UPS Ground · tracked + insured · released after independent lab testing
- Purity Guarantee. If a batch fails our ≥99% HPLC standard, full refund + replacement.
- Batch certificate in the COA library, anytime, free
- Same reorder price — forever, no upcharge
$64.99
Single
Semaglutide in brief
Semaglutide is an acylated GLP-1 receptor agonist peptide, one of the most extensively studied incretin analogs in metabolic research. Semaglutide is FDA-approved only as specific branded prescription drug products; research material sold as semaglutide is not one of those products and is not FDA-approved. Supplied for research use only.
— About this compound
Semaglutide.
Class · Long-acting glucagon-like peptide-1 (GLP-1) receptor agonist (acylated GLP-1 analog)
Origin. Developed by Novo Nordisk as a structurally engineered, albumin-binding analog of native GLP-1 designed for an extended half-life. The broader GLP-1 analog field grew out of incretin physiology characterized from the 1980s onward.
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1), a 31-amino-acid incretin hormone. Engineering modifications — a C18 fatty-diacid side chain that promotes reversible binding to serum albumin, plus substitutions that resist DPP-4 degradation — give it a markedly longer circulating half-life than native GLP-1, a central focus of the analog literature.
In research, semaglutide is used as a reference GLP-1 receptor agonist for studying incretin signaling, pancreatic islet biology, and energy-metabolism models. It is a regulated therapeutic in approved human channels; the Merit Sciences offering is supplied strictly for research use and not for human or veterinary administration.
— Common research applications
- GLP-1 receptor signaling research
- Incretin and islet-biology models
- Energy-metabolism and appetite-pathway studies
- Comparative GLP-1 analog pharmacology
— Mechanism
How it's been studied.
Selective agonism at the GLP-1 receptor, a class B G-protein-coupled receptor. Receptor engagement modulates glucose-dependent insulin secretion, glucagon release, and central pathways implicated in satiety in preclinical models.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
—
Molecular weight
—
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
10 mg
Purity (HPLC)
≥99%
Amino acids
—
Half-life
~7 days (engineered albumin binding; pharmacokinetic literature).
Solubility
Water-soluble. Physicochemical context only. Merit Sciences publishes no reconstitution or preparation procedures.
View the July 2026 batch certificate for Semaglutide 10 mg → or browse every certificate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Semaglutide.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
The Discovery and Development of Liraglutide and Semaglutide
Knudsen LB, Lau J · Frontiers in Endocrinology · 2019
- 02
GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art
Nauck MA, Quast DR, Wefers J, et al. · Molecular Metabolism · 2021
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Go deeper
Mechanism, published research and peer-reviewed references for Semaglutide, with no product attached.
— Common Questions
Got questions.
Is Semaglutide FDA-approved?+
Semaglutide is FDA-approved only as specific branded prescription drug products; research material sold as semaglutide is not one of those products and is not FDA-approved. Supplied for research use only.
How is each batch of Semaglutide tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed. Merit identifies batches by date: the current certificate for Semaglutide 10 mg is the July 2026 batch, 99.47% purity by HPLC, published at meritsciences.com/coa/COA-2026-L_IYY7. The QR code on each vial opens the same page. Open the July 2026 batch certificate →
What does the published research on Semaglutide show?+
The STEP 1 trial (Wilding, NEJM 2021) reported a mean body-weight change of minus 14.9% versus minus 2.4% on placebo over 68 weeks in 1,961 adults with overweight or obesity. Reviews of the class (Nauck, Molecular Metabolism 2021) summarize its glycemic results in type 2 diabetes trials. The Semaglutide monograph at meritsciences.com/library/semaglutide lists the references. Read the Semaglutide monograph →
What is Semaglutide?+
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1), a 31-amino-acid incretin hormone. Engineering modifications — a C18 fatty-diacid side chain that promotes reversible binding to serum albumin, plus substitutions that resist DPP-4 degradation — give it a markedly longer circulating half-life than native GLP-1, a central focus of the analog literature.
How does Semaglutide work?+
Selective agonism at the GLP-1 receptor, a class B G-protein-coupled receptor. Receptor engagement modulates glucose-dependent insulin secretion, glucagon release, and central pathways implicated in satiety in preclinical models.
What class of compound is Semaglutide?+
Semaglutide is classified as long-acting glucagon-like peptide-1 (GLP-1) receptor agonist (acylated GLP-1 analog).
What is the reported half-life of Semaglutide?+
~7 days (engineered albumin binding; pharmacokinetic literature).
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
Question we didn't answer?
Our team answers compound and batch questions the same business day. No bots, no tickets.
Email the team →