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DSIP 5 mg
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DSIP in brief
DSIP is delta sleep-inducing peptide, a nine-amino-acid peptide first isolated from rabbits in 1977 and studied in sleep and EEG research. DSIP (emideltide) is not approved by the FDA for any use, and an FDA advisory committee voted against recommending it for the 503A compounding list in July 2026. Supplied for research use only.
— About this compound
DSIP.
Class · Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) with no identified gene, precursor protein or receptor
Origin. Isolated from rabbits and sequenced in 1977 by Schoenenberger and Monnier in Basel, who named it for the delta (slow-wave) EEG activity it was reported to induce.
Delta sleep-inducing peptide (DSIP, also listed as emideltide) is a nine-amino-acid peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. Schoenenberger and Monnier reported it in 1977 after isolating it from rabbits. In double-blind infusions into the brain ventricles of rabbits, synthetic DSIP enhanced delta and spindle EEG patterns, while the fragments and analogs tested alongside it did not (PNAS 1977).
Nearly five decades later its biology remains unsettled. A 1986 review in Peptides described its physiological functions and mechanism of action as still to be established, and a 2006 review in the Journal of Neurochemistry noted that no DSIP gene, precursor protein or receptor had been isolated and that the link between DSIP and sleep had never been established.
The human literature is small and dated. A double-blind, matched-pairs study in 16 adults with chronic insomnia (Neuropsychobiology 1992) reported changes in sleep measures that its authors judged weak, and concluded that DSIP was unlikely to be of major benefit. These findings are reported as literature only. Merit Sciences supplies DSIP strictly for laboratory research use, not for human or veterinary use.
— Common research applications
- Sleep and EEG neurophysiology in animal models
- Neuropeptide structure-activity studies
- Blood-brain barrier peptide transport
- History and methods of sleep-factor research
— Mechanism
How it's been studied.
No mechanism has been established. Because no receptor or gene has been identified, proposed actions rest on indirect evidence. Early rabbit work reported increased cortical delta activity and reduced motor activity for several hours after peripheral administration, which its authors read as passage across the blood-brain barrier (Experientia 1977). A 2006 review proposed that an unidentified DSIP-like peptide accounts for the DSIP immunoreactivity reported in many tissues, and noted that certain synthetic analogs, but not DSIP itself, promoted slow-wave sleep in the authors' own rabbit and rat studies.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
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Molecular weight
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Formula
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Sequence
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Format
Lyophilized powder
Vial dose
5 mg
Purity (HPLC)
≥99%
Amino acids
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Half-life
—
Solubility
—
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for DSIP.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Characterization of a delta-electroencephalogram (-sleep)-inducing peptide
Schoenenberger GA, Monnier M · Proceedings of the National Academy of Sciences of the United States of America · 1977
- 02
Transport of the synthetic peptide DSIP through the blood-brain barrier in rabbit
Monnier M, Dudler L, Gachter R, Schoenenberger GA · Experientia · 1977
- 03
Delta-sleep-inducing peptide (DSIP): an update
Graf MV, Kastin AJ · Peptides · 1986
- 04
Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study
Bes F, Hofman W, Schuur J, Van Boxtel C · Neuropsychobiology · 1992
- 05
Delta sleep-inducing peptide (DSIP): a still unresolved riddle
Kovalzon VM, Strekalova TV · Journal of Neurochemistry · 2006
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Go deeper
Mechanism, published research and peer-reviewed references for DSIP, with no product attached.
Research review on The Assay, Merit’s editorial publication: DSIP: What the Delta Sleep-Inducing Peptide Research Shows
— Common Questions
Got questions.
Is DSIP FDA-approved?+
DSIP (emideltide) is not approved by the FDA for any use, and an FDA advisory committee voted against recommending it for the 503A compounding list in July 2026. Supplied for research use only.
How is each batch of DSIP tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed, and Merit identifies batches by date rather than by lot number. Published certificates are in the COA library at meritsciences.com/coa, searchable by compound; the QR code on each vial opens its certificate. Search the COA library →
What does the published research on DSIP show?+
Schoenenberger and Monnier (PNAS 1977) reported that synthetic DSIP enhanced delta and spindle EEG patterns when infused into the brain ventricles of rabbits. A double-blind study in 16 adults with chronic insomnia (Neuropsychobiology 1992) reported weak effects that its authors judged unlikely to be of major benefit. The DSIP monograph at meritsciences.com/library/dsip lists the references, and The Assay, Merit's editorial publication, reviews the evidence at theassay.co/articles/dsip-research-review. Read the DSIP monograph →
What is DSIP?+
Delta sleep-inducing peptide (DSIP, also listed as emideltide) is a nine-amino-acid peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. Schoenenberger and Monnier reported it in 1977 after isolating it from rabbits. In double-blind infusions into the brain ventricles of rabbits, synthetic DSIP enhanced delta and spindle EEG patterns, while the fragments and analogs tested alongside it did not (PNAS 1977).
How does DSIP work?+
No mechanism has been established. Because no receptor or gene has been identified, proposed actions rest on indirect evidence. Early rabbit work reported increased cortical delta activity and reduced motor activity for several hours after peripheral administration, which its authors read as passage across the blood-brain barrier (Experientia 1977). A 2006 review proposed that an unidentified DSIP-like peptide accounts for the DSIP immunoreactivity reported in many tissues, and noted that certain synthetic analogs, but not DSIP itself, promoted slow-wave sleep in the authors' own rabbit and rat studies.
What class of compound is DSIP?+
DSIP is classified as nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) with no identified gene, precursor protein or receptor.
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
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