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5-Amino-1MQ 50 mg
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$64.99
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5-Amino-1MQ in brief
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme linking NAD+ salvage and methylation, studied in cell and mouse models of obesity and adipocyte metabolism. It is not a peptide. Not approved by the FDA for any use. Supplied for research use only.
— About this compound
5-Amino-1MQ.
Class · Small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor (5-amino-1-methylquinolinium)
Origin. Reported by Neelakantan and colleagues in 2018 as part of medicinal-chemistry work on membrane-permeable NNMT inhibitors developed to probe NNMT’s role in adipocyte energy metabolism.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. Unlike the catalog’s peptides, it is a low-molecular-weight quinolinium compound, not an amino-acid chain.
Research interest centers on NNMT’s position at the intersection of the NAD+ salvage pathway and SAM-dependent methylation. Preclinical models have investigated whether NNMT inhibition shifts adipocyte energy expenditure and cellular NAD+ availability. Supplied for research use only.
— Common research applications
- NNMT enzyme-inhibition research
- NAD+ salvage-pathway studies
- Adipocyte energy-metabolism models
- Cellular methylation (SAM/SAH) research
— Mechanism
How it's been studied.
Competitive inhibition of NNMT, reducing enzymatic methylation of nicotinamide. Proposed downstream effects in the literature include preservation of nicotinamide for NAD+ salvage and modulation of the cellular SAM/SAH methylation balance in adipocyte models.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
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Molecular weight
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Formula
—
Sequence
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Format
Lyophilized powder
Vial dose
50 mg
Purity (HPLC)
≥99%
Amino acids
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Half-life
Not well-characterized in the public literature; small-molecule pharmacokinetics differ from the catalog peptides.
Solubility
Water-soluble. Physicochemical context only. Merit Sciences publishes no reconstitution or preparation procedures.
View the May 2026 batch certificate for 5-Amino-1MQ 50 mg → or browse every certificate.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for 5-Amino-1MQ.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- Licensed US facility
- Batch-documented manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing support@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
Neelakantan H, Vance V, Wetzel MD, et al. · Biochemical Pharmacology · 2018
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Go deeper
Mechanism, published research and peer-reviewed references for 5-Amino-1MQ, with no product attached.
— Common Questions
Got questions.
Is 5-Amino-1MQ FDA-approved?+
Not approved by the FDA for any use. Supplied for research use only.
How is each batch of 5-Amino-1MQ tested?+
Every batch is tested by an independent laboratory for identity and HPLC purity before it is listed. Merit identifies batches by date: the current certificate for 5-Amino-1MQ 50 mg is the May 2026 batch, 99.429% purity by HPLC, published at meritsciences.com/coa/MRT-2605-12. The QR code on each vial opens the same page. Open the May 2026 batch certificate →
What does the published research on 5-Amino-1MQ show?+
Neelakantan (Biochemical Pharmacology 2018) reported that selective NNMT inhibitors, including 5-amino-1MQ, reduced body weight and white adipose mass in mice with diet-induced obesity. No human trial has been published. The 5-Amino-1MQ monograph at meritsciences.com/library/5-amino-1mq lists the references. Read the 5-Amino-1MQ monograph →
What is 5-Amino-1MQ?+
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. Unlike the catalog’s peptides, it is a low-molecular-weight quinolinium compound, not an amino-acid chain.
How does 5-Amino-1MQ work?+
Competitive inhibition of NNMT, reducing enzymatic methylation of nicotinamide. Proposed downstream effects in the literature include preservation of nicotinamide for NAD+ salvage and modulation of the cellular SAM/SAH methylation balance in adipocyte models.
What class of compound is 5-Amino-1MQ?+
5-Amino-1MQ is classified as small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor (5-amino-1-methylquinolinium).
What is the reported half-life of 5-Amino-1MQ?+
Not well-characterized in the public literature; small-molecule pharmacokinetics differ from the catalog peptides.
Why does Merit ship lyophilized?+
Lyophilized (freeze-dried) material is stable in sealed storage: ≥24 months at -20°C. Peptides held in solution degrade far faster, so every compound ships as a dry powder in a sealed vial.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do, which is what separates Merit from a reseller catalog.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
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