— Research monograph
5-Amino-1MQ
A small-molecule NNMT inhibitor studied in metabolic and adipocyte models.
- Class
- Small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor (5-amino-1-methylquinolinium)
- Half-life (research)
- Not well-characterized in the public literature; small-molecule pharmacokinetics differ from the catalog peptides.
- Origin
- Reported by Neelakantan and colleagues in 2018 as part of medicinal-chemistry work on membrane-permeable NNMT inhibitors developed to probe NNMT’s role in adipocyte energy metabolism.
- Solubility
- Water-soluble; reconstitutes in bacteriostatic water.
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. Unlike the catalog’s peptides, it is a low-molecular-weight quinolinium compound, not an amino-acid chain.
Research interest centers on NNMT’s position at the intersection of the NAD+ salvage pathway and SAM-dependent methylation. Preclinical models have investigated whether NNMT inhibition shifts adipocyte energy expenditure and cellular NAD+ availability. Supplied for research use only.
How does 5-Amino-1MQ work?
Competitive inhibition of NNMT, reducing enzymatic methylation of nicotinamide. Proposed downstream effects in the literature include preservation of nicotinamide for NAD+ salvage and modulation of the cellular SAM/SAH methylation balance in adipocyte models.
Research applications
- NNMT enzyme-inhibition research
- NAD+ salvage-pathway studies
- Adipocyte energy-metabolism models
- Cellular methylation (SAM/SAH) research
Handling & reconstitution
5-Amino-1MQ ships as a sealed, lyophilized (freeze-dried) powder and is reconstituted with bacteriostatic water for laboratory handling. Water-soluble; reconstitutes in bacteriostatic water. Concentration equals vial mass divided by diluent volume.
Frequently asked questions
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. Unlike the catalog’s peptides, it is a low-molecular-weight quinolinium compound, not an amino-acid chain. Merit supplies it as a lyophilized research compound for research use only — not for human or veterinary use.
How does 5-Amino-1MQ work?
Competitive inhibition of NNMT, reducing enzymatic methylation of nicotinamide. Proposed downstream effects in the literature include preservation of nicotinamide for NAD+ salvage and modulation of the cellular SAM/SAH methylation balance in adipocyte models. Mechanistic descriptions summarize published preclinical findings and are not clinical claims.
What is the half-life of 5-Amino-1MQ?
Not well-characterized in the public literature; small-molecule pharmacokinetics differ from the catalog peptides. Values reflect preclinical or research-context reports, not clinical pharmacokinetics.
Is Merit 5-Amino-1MQ for human use?
No. It is sold strictly for research use only — not for human or veterinary use, and not for diagnostic or therapeutic use. Every lot ships with a certificate of analysis documenting ≥99% HPLC purity.
References
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Neelakantan H, Vance V, Wetzel MD, et al.. Biochemical Pharmacology, 2018 · doi:10.1016/j.bcp.2018.01.019
For research use only. Not for human or veterinary use. Not FDA-approved. Reference information summarized from published literature — not medical or dosing advice.