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HPLC-Verified
US Pharmacist
Same Reorder Price
Neuropeptides · HEPTAPEPTIDE
Semax 10 mg
Lyophilized vial · 7 AA
Semax — pharmacy-verified, lot-tested, and shipped from our facility in Dallas. Released only after a US-licensed pharmacist signs off on the batch.
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Single- Purity Guarantee. If a lot fails our ≥99% HPLC standard, full refund + replacement.
- Lot-specific COA on demand — anytime, free
- Same reorder price — forever, no upcharge
$55.99
Single
— About this compound
Semax.
Class · Synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) — ACTH(4-10) analog
Origin. Developed at Moscow State University by the Ashmarin laboratory in the 1980s. Designed as an N-terminal ACTH fragment with the C-terminal Pro-Gly-Pro extension for proteolytic stability. Approved in Russia as a nootropic.
Semax is a synthetic heptapeptide composed of an N-terminal ACTH(4-7) tetrapeptide (Met-Glu-His-Phe) extended with the C-terminal tripeptide Pro-Gly-Pro. The Pro-Gly-Pro extension dramatically increases plasma stability compared to the parent ACTH fragment.
Semax is one of the most-studied compounds in the Russian neuropeptide literature, with a substantial body of preclinical work on neurotrophic factor expression, monoamine neurotransmission, and behavioral models.
— Common research applications
- Neurotrophic factor research (BDNF, NGF)
- Monoamine neurotransmission studies
- Cognitive-pathway preclinical models
- Nootropic-class peptide pharmacology
— Mechanism
How it's been studied.
Modulates BDNF and NGF expression in cultured glial cells and rodent brain tissue. Affects dopaminergic and serotonergic neurotransmission in preclinical models. Specific receptor targets continue to be characterized.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
80714-61-0
Molecular weight
813.9 Da
Formula
—
Sequence
MEHFPGP
Format
Lyophilized powder
Vial dose
10 mg
Purity (HPLC)
≥99%
Amino acids
7
Half-life
Short circulating half-life; intranasal administration is the primary route in research protocols.
Solubility
Highly water-soluble; commonly formulated as an intranasal solution.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for Semax.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit lot follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- ISO-certified US facility
- ISO-certified manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every lot before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-lot
- ≥99% purity floor — every batch
- Chromatogram archived for every lot
- 04
Sign-off
A US-licensed pharmacist releases the lot.
No batch ships without a pharmacist reviewing the chromatogram, identity report, and lot documentation. The pharmacist holds the release authority.
- US-licensed pharmacist on every lot
- Pharmacist holds release authority
- No batch ships unsigned — ever
- 05
Dispatch
Ships from Dallas in 48 hours.
Vials labeled with lot ID, tested date, and CAS. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from Dallas, TX
- Lot ID printed on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific lot by emailing rx@meritsciences.com with the lot number from your vial label.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents
Eremin KO, Kudrin VS, Saransaari P, et al. · Neurochemistry Research · 2005
- 02
Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. · Journal of Neurochemistry · 2006
- 03
Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog
Shadrina MI, Dolotov OV, Grivennikov IA, et al. · Neuroscience Letters · 2001
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Pairs Well With
Researchers stack this with.
The Neuropeptide Pair
Russian heptapeptides
Selank and Semax — the two most-studied compounds in neuropeptide research, almost always stacked together.
$111.98 · save 10%
— Common Questions
Got questions.
What is Semax?+
Semax is a synthetic heptapeptide composed of an N-terminal ACTH(4-7) tetrapeptide (Met-Glu-His-Phe) extended with the C-terminal tripeptide Pro-Gly-Pro. The Pro-Gly-Pro extension dramatically increases plasma stability compared to the parent ACTH fragment.
How does Semax work?+
Modulates BDNF and NGF expression in cultured glial cells and rodent brain tissue. Affects dopaminergic and serotonergic neurotransmission in preclinical models. Specific receptor targets continue to be characterized.
What class of compound is Semax?+
Semax is classified as synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) — ACTH(4-10) analog.
What is the reported half-life of Semax?+
Short circulating half-life; intranasal administration is the primary route in research protocols.
Why does Merit ship lyophilized?+
Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.
How do I verify my lot's COA?+
Your vial label carries the lot number. Use that number to pull the COA on our site at any time — the COA for your specific batch lives at /coa/[lot-id] and stays accessible for the life of the product.
What does "pharmacy-verified" actually mean?+
A US-licensed pharmacist on our team reviews every batch before release. They sign off on the lot's purity, identity, and release. No batch ships without that sign-off — and that's what separates Merit from a reseller catalog.
Will my bank flag this purchase?+
Statements show as Merit Sciences LLC. Standard merchant descriptor — does not trigger category-code flags. All major cards and PayPal accepted at checkout.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From Dallas, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
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