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GLPs · DUAL GIP/GLP RECEPTOR AGONIST
TZ2 - LY3298176 30 mg
Lyophilized vial · 39 AA
TZ2 - LY3298176 — independently assayed, batch-tested, and shipped from our fulfillment facility in San Antonio. Released only after an independent laboratory returns its results for the batch.
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SingleShips within 48 hours from San Antonio
UPS Ground · tracked + insured · released after independent lab testing
- Purity Guarantee. If a batch fails our ≥99% HPLC standard, full refund + replacement.
- Batch certificate in the COA library, anytime, free
- Same reorder price — forever, no upcharge
$149.99
Single
— About this compound
TZ2 - LY3298176.
Class · Dual GIP / GLP-1 receptor agonist (synthetic 39-amino-acid peptide)
Origin. Developed by Eli Lilly. First characterized in the open scientific literature in 2018 (Coskun et al.). Approved by the FDA as Mounjaro (2022) for type 2 diabetes and as Zepbound (2023) for chronic weight management.
Tirzepatide (research code LY3298176) is a synthetic 39-amino-acid peptide engineered to act as a single-molecule dual agonist at the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. The molecule incorporates a C20 fatty-acid moiety that supports extended duration of action via albumin binding.
Tirzepatide is a regulated therapeutic compound approved for human use under separate brand names in regulated channels. The Merit Sciences offering is supplied for research use only — not for human or veterinary administration. Researchers must confirm jurisdictional eligibility before procurement.
— Common research applications
- Incretin signaling research
- Glucose homeostasis models
- Dual receptor pharmacology
- Body weight regulation studies
- Comparative GLP-1 / GIP agonist work
— Mechanism
How it's been studied.
Binds and activates both the GIP receptor and the GLP-1 receptor with picomolar affinity. The dual-incretin pharmacology is reported to produce additive effects on insulin secretion and glucagon suppression in preclinical metabolic research models.
Mechanism descriptions reflect findings reported in the preclinical and basic-research literature. They are not clinical conclusions and not statements of therapeutic effect.
— The Chemistry
The numbers, plainly.
CAS
2023788-19-2
Molecular weight
4813.5 Da
Formula
—
Sequence
—
Format
Lyophilized powder
Vial dose
30 mg
Purity (HPLC)
≥99%
Amino acids
39
Half-life
~5 days (preclinical and clinical).
Solubility
Reconstitutes in bacteriostatic water; clear solution.
View lab results for TZ2 - LY3298176 → or search by compound.
— Why Merit
The supplier difference.
How Merit compares to the two alternatives most research buyers consider for TZ2 - LY3298176.
Comparison reflects published facility status and standard industry practice. Compounding pharmacy availability of research peptides varies by jurisdiction.
— How it's made
From compound to your shelf.
Every Merit batch follows the same documented path. Five steps, every one verifiable.
- 01
Sourcing
Compound starts as a research-grade API.
Active pharmaceutical ingredient sourced from FDA-registered manufacturers. Identity confirmed against reference standard before any compounding begins.
- API from FDA-registered manufacturers
- Identity verified against reference standard
- Chain of custody documented
- 02
Compounding
Sterile-filled in a US cleanroom.
Lyophilized in a cleanroom at our US facility. The powder format gives ≥24 months sealed stability — no cold-chain shipping required.
- ISO-certified US facility
- ISO-certified manufacturing process
- Lyophilized powder for transit stability
- 03
Verification
Every batch HPLC-tested.
Reverse-phase HPLC-UV (UV/MS for higher-MW peptides) confirms identity and purity for every batch before it leaves the lab. The chromatogram is archived.
- Reverse-phase HPLC, per-batch
- ≥99% purity floor — every batch
- Chromatogram archived for every batch
- 04
Release
The batch is released against an independent assay.
No batch ships until an independent laboratory has returned its identity and purity results and the certificate is published in the COA library.
- Independent laboratory on every batch
- Certificate published before sale
- Every certificate is in the public COA library
- 05
Dispatch
Ships from San Antonio in 48 hours.
Sealed vials with a QR code on the label that opens the COA library. Order before 2pm CT Monday–Thursday for same-day dispatch. UPS Ground, tracked + insured.
- 48hr dispatch from San Antonio, TX
- QR code on every vial label
- UPS Ground, tracked + insured
Every step above can be verified for any specific batch by emailing rx@meritsciences.com with your order number.
— Research references
The published record.
Peer-reviewed work cited in the public scientific literature. Links resolve to PubMed or the publisher of record.
- 01
LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus
Coskun T, Sloop KW, Loghin C, et al. · Molecular Metabolism · 2018
- 02
Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
Frias JP, Nauck MA, Van J, et al. · The Lancet · 2018
- 03
Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes
Frias JP, Davies MJ, Rosenstock J, et al. · New England Journal of Medicine · 2021
- 04
Tirzepatide Once Weekly for the Treatment of Obesity
Jastreboff AM, Aronne LJ, Ahmad NN, et al. · New England Journal of Medicine · 2022
Inclusion of a reference does not constitute a clinical claim or recommendation.
— Common Questions
Got questions.
What is TZ2 - LY3298176?+
Tirzepatide (research code LY3298176) is a synthetic 39-amino-acid peptide engineered to act as a single-molecule dual agonist at the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. The molecule incorporates a C20 fatty-acid moiety that supports extended duration of action via albumin binding.
How does TZ2 - LY3298176 work?+
Binds and activates both the GIP receptor and the GLP-1 receptor with picomolar affinity. The dual-incretin pharmacology is reported to produce additive effects on insulin secretion and glucagon suppression in preclinical metabolic research models.
What class of compound is TZ2 - LY3298176?+
TZ2 - LY3298176 is classified as dual GIP / GLP-1 receptor agonist (synthetic 39-amino-acid peptide).
What is the reported half-life of TZ2 - LY3298176?+
~5 days (preclinical and clinical).
Why does Merit ship lyophilized?+
Lyophilized format gives ≥24 months sealed stability at -20°C — significantly longer than pre-reconstituted, which has a 30-day shelf life once in solution. You reconstitute at the moment of use, when potency is at its peak.
How do I check the certificate for my batch?+
The QR code on every vial opens our COA library. Search by compound to find the certificate for the batch currently shipping. No account and no request form, and the library keeps every certificate we have released.
What does "independently assayed" actually mean?+
Every batch is tested by a laboratory independent of the facility that made it, and the certificate is published before the batch is listed. You read the same identity and purity figures we do — that's what separates Merit from a reseller catalog.
Will my bank flag this purchase?+
Statements show as Merit Sciences LLC. Standard merchant descriptor — does not trigger category-code flags. All major cards and PayPal accepted at checkout.
How fast does it ship?+
48 hours from order to dispatch, Monday through Thursday. UPS Ground, tracked + insured. From San Antonio, TX, most US addresses receive within 3-5 business days.
— Talk to a Pharmacologist
Question we didn't answer?
Our team answers compound questions, batch questions, and protocol questions — same business day. No bots, no tickets.
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