— Research monograph
Selank
A synthetic heptapeptide analog of tuftsin studied in anxiolytic models.
- Class
- Synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) — tuftsin analog
- Half-life (research)
- Short circulating half-life; CNS effects reported well beyond serum-detectable window in research models.
- Origin
- Developed in Russia at the Institute of Molecular Genetics of the Russian Academy of Sciences. Designed as a stabilized analog of the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg).
- Solubility
- Soluble in bacteriostatic water; sublingual / intranasal formulations are common in the research literature.
What is Selank?
Selank is a synthetic heptapeptide consisting of the human tuftsin tetrapeptide (Thr-Lys-Pro-Arg) extended with the C-terminal tripeptide -Pro-Gly-Pro. The C-terminal extension confers significant proteolytic resistance, supporting longer in-vivo activity than the parent tuftsin.
Selank is one of two Russian-developed heptapeptides commonly co-studied in the neuropeptide literature; the other (Semax) is structurally distinct but is often cited alongside Selank in research on neurotrophic and behavioral endpoints.
How does Selank work?
Reported effects on GABAergic and serotonergic neurotransmission in preclinical research. Modulates BDNF and NGF expression in some rodent models. Acts intranasally or peripherally with reported CNS bioavailability.
Research applications
- Anxiolytic-pathway research
- BDNF / NGF expression studies
- Neuropeptide receptor research
- Comparative tuftsin-analog studies
Handling & reconstitution
Selank ships as a sealed, lyophilized (freeze-dried) powder and is reconstituted with bacteriostatic water for laboratory handling. Soluble in bacteriostatic water; sublingual / intranasal formulations are common in the research literature. Concentration equals vial mass divided by diluent volume.
Frequently asked questions
What is Selank?
Selank is a synthetic heptapeptide consisting of the human tuftsin tetrapeptide (Thr-Lys-Pro-Arg) extended with the C-terminal tripeptide -Pro-Gly-Pro. The C-terminal extension confers significant proteolytic resistance, supporting longer in-vivo activity than the parent tuftsin. Merit supplies it as a lyophilized research compound for research use only — not for human or veterinary use.
How does Selank work?
Reported effects on GABAergic and serotonergic neurotransmission in preclinical research. Modulates BDNF and NGF expression in some rodent models. Acts intranasally or peripherally with reported CNS bioavailability. Mechanistic descriptions summarize published preclinical findings and are not clinical claims.
What is the half-life of Selank?
Short circulating half-life; CNS effects reported well beyond serum-detectable window in research models. Values reflect preclinical or research-context reports, not clinical pharmacokinetics.
Is Merit Selank for human use?
No. It is sold strictly for research use only — not for human or veterinary use, and not for diagnostic or therapeutic use. Every lot ships with a certificate of analysis documenting ≥99% HPLC purity.
References
- The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Kolomin T, Shadrina M, Slominsky P, et al.. Molecular Immunology, 2013 · PMID 24291245
- Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Volkova A, Shadrina M, Kolomin T, et al.. Frontiers in Pharmacology, 2016 · PMID 26924987
For research use only. Not for human or veterinary use. Not FDA-approved. Reference information summarized from published literature — not medical or dosing advice.