CELLULAR RENEWAL · RESEARCH USE ONLY
- Independent third-party HPLC verified
- ≥99% purity floor on every lot
- Cold-chain shipping, signature required
CELLULAR RENEWAL · RESEARCH USE ONLY
MOTS-c — mitochondrial-derived peptide (MDP) encoded within mitochondrial 12S rRNA, studied in metabolic-homeostasis and AMPK-pathway research.
Compound identity
- Compound: MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA-c)
- CAS Number: 1627580-64-6
- Class: 16-amino-acid mitochondrial-derived peptide (MDP)
- Mechanism (in vitro): MOTS-c has been studied for activity in AMPK-pathway signaling and metabolic-homeostasis regulation
Research context
MOTS-c is a research peptide encoded within the mitochondrial 12S rRNA gene — one of the first identified mitochondrial-derived peptides. Published research has examined MOTS-c in mitochondrial-function studies, AMPK signaling pathways, glucose-regulation models, and longevity-pathway research. The compound is referenced in cellular-aging research and mitochondrial-pathway literature as a model peptide for investigating mitochondrial-nuclear signaling.
Vial composition
- 20 mg MOTS-c, lyophilized
- Sealed amber vial with aluminum crimp seal
Quality verification
- HPLC ≥99% purity, batch-specific Certificate of Analysis
- Mass spectrometry identity confirmation (matched molecular weight)
- Heavy metal and endotoxin panel testing per batch
- Synthesized in independently audited US laboratories with full toxicity and heavy-metal panels per batch
- Cold-chain shipped same business day from our US facility
Storage & handling
- Sealed lyophilized vial: store at -20°C, away from light (≥24 months stability)
- After reconstitution: refrigerate at 2–8°C, use within 30 days, protect from light
- Reconstitute with bacteriostatic water (included free with order)
- Avoid repeated freeze-thaw cycles
About Merit Sciences
Merit Sciences supplies third-party tested research-grade peptides to qualified researchers in the United States. Every batch undergoes independent HPLC and mass spectrometry verification. Certificates of Analysis are publicly available for each lot at meritsciences.com — researchers can review purity data before placing an order. Cold-chain shipping, same-day fulfillment, and lot-traceable batch documentation are standard on every order.
For laboratory research use only. Not for human or veterinary use. No medical claims made. By purchasing you certify that you are a qualified researcher 21 years or older and will use this material strictly in vitro. Merit Sciences Inc., Delaware, USA.
References
All Merit Peptides products are sold strictly for laboratory and scientific research use. They are not intended for human consumption, veterinary use, or any therapeutic application. These products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.
By purchasing, you confirm that you are a qualified researcher or licensed professional purchasing these compounds for in-vitro research, laboratory analysis, or other lawful scientific use. Resale, redistribution, or any human or animal application is strictly prohibited.
CELLULAR RENEWAL · RESEARCH USE ONLY
MOTS-c — mitochondrial-derived peptide (MDP) encoded within mitochondrial 12S rRNA, studied in metabolic-homeostasis and AMPK-pathway research.
Compound identity
- Compound: MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA-c)
- CAS Number: 1627580-64-6
- Class: 16-amino-acid mitochondrial-derived peptide (MDP)
- Mechanism (in vitro): MOTS-c has been studied for activity in AMPK-pathway signaling and metabolic-homeostasis regulation
Research context
MOTS-c is a research peptide encoded within the mitochondrial 12S rRNA gene — one of the first identified mitochondrial-derived peptides. Published research has examined MOTS-c in mitochondrial-function studies, AMPK signaling pathways, glucose-regulation models, and longevity-pathway research. The compound is referenced in cellular-aging research and mitochondrial-pathway literature as a model peptide for investigating mitochondrial-nuclear signaling.
Vial composition
- 20 mg MOTS-c, lyophilized
- Sealed amber vial with aluminum crimp seal
Quality verification
- HPLC ≥99% purity, batch-specific Certificate of Analysis
- Mass spectrometry identity confirmation (matched molecular weight)
- Heavy metal and endotoxin panel testing per batch
- Synthesized in independently audited US laboratories with full toxicity and heavy-metal panels per batch
- Cold-chain shipped same business day from our US facility
Storage & handling
- Sealed lyophilized vial: store at -20°C, away from light (≥24 months stability)
- After reconstitution: refrigerate at 2–8°C, use within 30 days, protect from light
- Reconstitute with bacteriostatic water (included free with order)
- Avoid repeated freeze-thaw cycles
About Merit Sciences
Merit Sciences supplies third-party tested research-grade peptides to qualified researchers in the United States. Every batch undergoes independent HPLC and mass spectrometry verification. Certificates of Analysis are publicly available for each lot at meritsciences.com — researchers can review purity data before placing an order. Cold-chain shipping, same-day fulfillment, and lot-traceable batch documentation are standard on every order.
For laboratory research use only. Not for human or veterinary use. No medical claims made. By purchasing you certify that you are a qualified researcher 21 years or older and will use this material strictly in vitro. Merit Sciences Inc., Delaware, USA.
References
RECONSTITUTION & RESEARCH PROTOCOLS
Emerging clinical evidenceResearch protocol intensities, summarized from published literature. The math is computed for the vial size you pick. Not a dosing recommendation.
Rodent literature well-replicated (Lee et al. 2015 Cell Metab). Human research limited but expanding.
Reference research protocols from published peer-reviewed studies. Each card cites its source. This calculator is not a dosing recommendation. For research use only. Selection of any specific protocol is the responsibility of the qualified investigator under appropriate institutional oversight.
RECONSTITUTION & STORAGE PROTOCOL
Procedure
- Allow vial to equilibrate to room temperature before reconstitution.
- Inject solvent slowly along the inner wall of the vial.
- Gently swirl until fully dissolved.
- Resulting solution should be clear and colorless.
Storage & stability
| Lyophilized | ≥24 months at -20°C, light-protected, sealed. |
| Reconstituted | 30 days at 2-8°C in original vial. |
For research use only. Protocol values are derived from established laboratory practice and published peptide handling literature. Specific experimental designs may require alternative reconstitution parameters.
| Identity | MOTS-c · confirmed by mass spectrometry |
| Appearance | White lyophilized powder |
| Net peptide content | 12.81 mg per vial |
| Label strength | 10 mg |
| Sample received | March 18, 2026 |
| Results reported | March 19, 2026 |
Mass spectrometry · observed m/z
Independently verified — 99.381% HPLC purity
See full lab results · Lot MRT-2603-200
All Merit Peptides products are sold strictly for laboratory and scientific research use. They are not intended for human consumption, veterinary use, or any therapeutic application. These products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.
By purchasing, you confirm that you are a qualified researcher or licensed professional purchasing these compounds for in-vitro research, laboratory analysis, or other lawful scientific use. Resale, redistribution, or any human or animal application is strictly prohibited.
RESEARCH FAQ
Common research questions.
How do you verify peptide purity?
Every batch is tested by an independent third-party laboratory using High-Performance Liquid Chromatography (HPLC) for purity quantification and mass spectrometry for structural identity. Lots that don't clear our 99% purity floor are not released. The full Certificate of Analysis is published on each product page.
Where is the Certificate of Analysis (COA) for the lot I'd receive?
Each product page links to the COA for the current shipping batch. After purchase, the COA for your specific lot is permanently attached to your order record. Past COAs are also accessible via your account.
How should I store the compounds when they arrive?
Lyophilized peptides are stored at –20°C, away from light. Storage protocols vary by compound; consult product COA. Materials supplied for in-vitro research only.
How fast do orders ship?
Orders placed before 2pm EST ship the same day from our US-based facility. Temperature-sensitive compounds ship in cold-chain insulated packaging with gel packs. Tracking is provided via email.
Are these products approved for human or veterinary use?
No. All products sold by Merit Peptides are intended strictly for laboratory and scientific research use only. They have not been evaluated by the U.S. Food and Drug Administration and are not for human consumption, veterinary use, or any therapeutic application.
What are your bulk and volume pricing tiers?
Tiered discounts apply automatically at checkout: 10% off when you order 3 or more of any compound, 15% off on orders of 6 or more, and 20% off on orders of 12 or more. No coupon code required.
Are your products manufactured in the US?
Yes. All Merit Peptides compounds are synthesized and formulated in independently audited US laboratories with full toxicity and heavy-metal panels per batch. Our manufacturing partners follow current Good Manufacturing Practice (cGMP) guidelines.
What if my compound arrives damaged or my COA doesn't match?
Contact info@meritpeptides.com within 7 days. We'll replace the compound or refund the order. Every shipment is matched to the COA on file before it leaves the facility.